User profiles for Najaf Amin
Najaf AminUniversity of Oxford Verified email at ndph.ox.ac.uk Cited by 68658 |
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
…, A Ganna, N Paynter, KL Monda, N Amin… - Molecular …, 2015 - nature.com
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …
the world and has received considerable attention regarding health risks and benefits. We …
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
Genetic studies of body mass index yield new insights for obesity biology
…, J Karjalainen, EM Schmidt, D Absher, N Amin… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…
obesity better, here we conduct a genome-wide association study and Metabochip meta-…
[HTML][HTML] New insights into the genetic etiology of Alzheimer's disease and related dementias
…, IE Jansen, L Kleineidam, S Moreno-Grau, N Amin… - Nature …, 2022 - nature.com
Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
…, R Welch, JH Zhao, KK Aben, DM Absher, N Amin… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
…, I Surakka, ML Tammesoo, EL Altmaier, N Amin… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
…, LJ McCulloch, T Ferreira, H Grallert, N Amin… - Nature …, 2010 - nature.com
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…
and 38,987 controls of European descent and following up previously unidentified meta-…
Defining the role of common variation in the genomic and biological architecture of adult human height
…, AY Chu, K Estrada, J Luan, Z Kutalik, N Amin… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …
significance that together explained one-fifth of the heritability for adult height. By testing …
New genetic loci link adipose and insulin biology to body fat distribution
…, B Kahali, CT Liu, EM Schmidt, D Absher, N Amin… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
Genome-wide association study identifies 74 loci associated with educational attainment
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …