Rationale: Sepsis induces a sustained immune dysfunction responsible for poor outcome
and nosocomial infections. Myeloid-derived suppressor cells (MDSCs) described in cancer …

Exaggerated release of neutrophil extracellular traps (NETs) along with decreased NET
clearance and inability to remove apoptotic cells (efferocytosis) may contribute to sustained …

Purpose The SARS-CoV-2 infection can lead to a severe acute respiratory distress syndrome
(ARDS) with prolonged mechanical ventilation and high mortality rate. Interestingly, COVID…

Both tumor-associated neutrophils (TAN) and cancer-associated fibroblasts (CAFs) display
specific phenotypic and functional features and contribute to tumor cell niche. However, their …

Sepsis is accompanied by the initial activation of proinflammatory pathways and long-lasting
immunosuppression that appears to contribute to late-occurring mortality. Although high-…

Although resistin was recently found to modulate insulin resistance in preclinical models of
type II diabetes and obesity, recent studies also suggested that resistin has proinflammatory …

Severe sepsis induces a sustained immune dysfunction associated with poor clinical behavior.
In particular, lymphopenia along with increased lymphocyte apoptosis and decreased …

Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to
bacterial infections. AMPK and Parkin ubiquitin ligase are known to regulate mitochondrial …

Acute respiratory distress syndrome (ARDS) is the main complication of coronavirus disease
2019 (COVID-19), requiring admission to the intensive care unit (ICU). Despite extensive …

Cardiac surgery with cardiopulmonary bypass (CPB) induces postoperative immunosuppression
and impaired pulmonary function. Maintaining mechanical ventilation (MV) during CPB …