This narrative review summarizes the role of vitamin C in mitigating oxidative injury-induced
microcirculatory impairment and associated organ failure in ischemia/reperfusion or sepsis. …

Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident:
it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To …

The Fibulins are a 6-member protein family hypothesized to function as intermolecular
bridges that stabilize the organization of extracellular matrix structures. Here, we show that …

The extent and mechanism of the cardiac benefit of early exercise training following myocardial
infarction (MI) is incompletely understood, but may involve blunting of abnormalities in …

Mouse myocardial infarction (MI) models are frequently used research tools. The most commonly
applied model is coronary artery ligation. However, coronary ligation often gives rise to …

Aging is associated with reduced function, degenerative changes, and increased neuroinflammation
of the central nervous system (CNS). Increasing evidence suggests that changes in …

Age-related cognitive decline and neurodegenerative diseases are a growing challenge for
our societies with their aging populations. Accumulation of DNA damage has been …

Pompe disease (acid α-glucosidase deficiency) is a lysosomal glycogen storage disorder
characterized in its most severe early-onset form by rapidly progressive muscle weakness and …

Degeneration of motor neurons contributes to senescence-associated loss of muscle function
and underlies human neurodegenerative conditions such as amyotrophic lateral sclerosis …

Objective: Infused C‐type natriuretic peptide (CNP) was recently found to play a cardioprotective
role in preventing myocardial ischaemia/reperfusion (I/R) injury and improving cardiac …