[HTML][HTML] Relationships between viral load and the clinical course of COVID-19
…, D Shinoda, M Saito, K Okayama, M Sada… - Viruses, 2021 - mdpi.com
To predict the clinical outcome of coronavirus disease-2019 (COVID-19), we examined
relationships among epidemiological data, viral load, and disease severity. We examined viral …
relationships among epidemiological data, viral load, and disease severity. We examined viral …
IL-17A synergistically stimulates TNF-α-induced IL-8 production in human airway epithelial cells: a potential role in amplifying airway inflammation
…, M Nakamura, K Nakamoto, T Inui, M Sada… - Experimental lung …, 2016 - Taylor & Francis
Background: Recent reports have suggested an involvement of neutrophilic inflammation
driven by interleukin (IL)-17 from Th17 cells, especially in severe, refractory asthma. It remains …
driven by interleukin (IL)-17 from Th17 cells, especially in severe, refractory asthma. It remains …
[HTML][HTML] All-trans retinoic acid exhibits antiviral effect against SARS-CoV-2 by inhibiting 3CLpro activity
…, K Miyakawa, SS Jeremiah, Y Yamaoka, M Sada… - Viruses, 2021 - mdpi.com
The pandemic of COVID-19 caused by SARS-CoV-2 continues to spread despite the global
efforts taken to control it. The 3C-like protease (3CLpro), the major protease of SARS-CoV-2, …
efforts taken to control it. The 3C-like protease (3CLpro), the major protease of SARS-CoV-2, …
[HTML][HTML] Detailed molecular interactions of favipiravir with SARS-CoV-2, SARS-CoV, MERS-CoV, and influenza virus polymerases in silico
M Sada, T Saraya, H Ishii, K Okayama, Y Hayashi… - Microorganisms, 2020 - mdpi.com
Favipiravir was initially developed as an antiviral drug against influenza and is currently
used in clinical trials against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …
used in clinical trials against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …
Pseudomonas aeruginosa-derived flagellin stimulates IL-6 and IL-8 production in human bronchial epithelial cells: A potential mechanism for progression and …
K Nakamoto, M Watanabe, M Sada, T Inui… - Experimental Lung …, 2019 - Taylor & Francis
Background and purpose of the study: Pseudomonas aeruginosa commonly colonizes the
airway of patients with chronic obstructive pulmonary disease (COPD) and exacerbates their …
airway of patients with chronic obstructive pulmonary disease (COPD) and exacerbates their …
Bronchial epithelial cells produce CXCL1 in response to LPS and TNFα: A potential role in the pathogenesis of COPD
T Inui, M Watanabe, K Nakamoto, M Sada… - Experimental Lung …, 2018 - Taylor & Francis
Rationale: Neutrophilic airway inflammation plays a central role in chronic obstructive pulmonary
disease (COPD). CXC chemokine ligand (CXCL)1 is a neutrophil chemokine involved …
disease (COPD). CXC chemokine ligand (CXCL)1 is a neutrophil chemokine involved …
[HTML][HTML] Serum sST2 levels predict severe exacerbation of asthma
M Watanabe, K Nakamoto, T Inui, M Sada, K Honda… - Respiratory …, 2018 - Springer
Background Neutrophilic inflammation is associated with poorly controlled asthma. Serum
levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We …
levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We …
Molecular pharmacology of ciclesonide against SARS-CoV-2
H Kimura, H Kurusu, M Sada, D Kurai… - Journal of allergy and …, 2020 - jacionline.org
The full-length nucleotide sequences of NSP15 and RdRp (RNA-dependent RNA
polymerase) genes identified in GenBank (accession no. MN908947) were used for homology …
polymerase) genes identified in GenBank (accession no. MN908947) were used for homology …
[HTML][HTML] Rhinovirus infection and virus-induced asthma
Y Hayashi, M Sada, T Shirai, K Okayama, R Kimura… - Viruses, 2022 - mdpi.com
While the aetiology of asthma is unclear, the onset and/or exacerbation of asthma may be
associated with respiratory infections. Virus-induced asthma is also known as virus-associated/…
associated with respiratory infections. Virus-induced asthma is also known as virus-associated/…
Molecular diversity of human respiratory syncytial virus before and during the COVID-19 pandemic in two neighboring Japanese cities
…, H Okabe, M Sato, S Norito, J Aso, M Sada… - Microbiology …, 2023 - Am Soc Microbiol
Human respiratory syncytial viruses (HRSVs) are divided into subgroups A and B, which are
further divided based on the nucleotide sequence of the second hypervariable region (HVR…
further divided based on the nucleotide sequence of the second hypervariable region (HVR…