Rationale: Studies of excised lungs show that significant airway attrition in the “quiet” zone
occurs early in chronic obstructive pulmonary disease (COPD). Objectives: To determine if the …

RATIONALE AND OBJECTIVES: To improve intra- and interobserver variability and enable
the use of functional magnetic resonance imaging (MRI) for multicenter, multiobserver studies…

Purpose To quantitatively compare hyperpolarized helium 3 ( 3 He) and xenon 129 ( 129 Xe)
magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and …

Background There is limited data on the risk factors and phenotypical characteristics associated
with spirometrically confirmed COPD in never-smokers in the general population. Aims …

Background The concept that small conducting airways less than 2 mm in diameter become
the major site of airflow obstruction in chronic obstructive pulmonary disease (COPD) is well …

… Kirby gratefully acknowledge scholarship support from the Natural Sciences and Engineering
Research Council (NSERC, Canada) and G. Parraga gratefully acknowledges support …

Importance Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD),
yet much of COPD risk remains unexplained. Objective To determine whether dysanapsis, …

Rationale: After adjustment for the amount of smoking, women have a 50% increased risk of
chronic obstructive pulmonary disease (COPD) compared with men. The anatomic basis and…

Background In patients with post-acute COVID-19 syndrome (PACS), abnormal gas-transfer
and pulmonary vascular density have been reported, but such findings have not been …

Purpose To quantitatively evaluate a small pilot group of ex-smokers with chronic obstructive
pulmonary disease (COPD) and healthy volunteers during approximately 2 years by using …