The polypeptide growth factor, hepatocyte growth factor/scatter factor (HGF/SF), shares the
multidomain structure and proteolytic mechanism of activation of plasminogen and other …

Little is known about the large ectodomain of MET, the product of the c-met protooncogene
and receptor for hepatocyte growth factor/scatter factor (HGF/SF). Here, we establish by …

Objective: To analyze interactions between the thyroid-stimulating hormone receptor (TSHR)
and a thyroid-stimulating human monoclonal autoantibody (M22) at the molecular level. …

We describe a general mass spectrometry approach to determine subunit stoichiometry and
lipid binding in intact membrane protein complexes. By exploring conditions for preserving …

Exchangeable apolipoproteins have been the subject of intense biomedical investigation for
decades. However, only in recent years the elucidation of the three-dimensional structure …

Background The Y chromosome of mammals is particularly prone to accumulate genes
related to male fertility. However, the high rate of molecular evolution on this chromosome …

The Escherichia coli protein RhlB is an ATP-dependent motor that unfolds structured RNA
for destruction by partner ribonucleases. In E. coli, and probably many other related γ-…

BAR domains are found in proteins that bind and remodel membranes and participate in
cytoskeletal and nuclear processes. Here, we report the crystal structure of the BAR domain …

In Gram-negative bacteria, drug resistance is due in part to the activity of transmembrane
efflux-pumps, which are composed of three types of proteins. A representative pump from …

Determination of the full-length thyroid-stimulating hormone receptor (TSHR) structure by
cryo-electron microscopy (cryo-EM) is described. The TSHR complexed with human …