Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased
susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient …

The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its
underlying mechanisms are poorly understood. We hypothesized that the epithelial cell–derived …

Rhinoviruses cause serious morbidity and mortality as the major etiological agents of
asthma exacerbations and the common cold. A major obstacle to understanding disease …

… Author links open overlay panel Michael R. Edwards a b c , Nathan W. Bartlett a b c ,
Deborah Clarke c d , Mark Birrell c d , Maria Belvisi c d , Sebastian L. Johnston a b c …

Rhinoviruses (RVs), which are the most common cause of virally induced asthma
exacerbations, account for much of the burden of asthma in terms of morbidity, mortality, and …

Rationale: Respiratory virus infections are associated with chronic obstructive pulmonary
disease (COPD) exacerbations, but a causative relationship has not been proven. Studies of …

The majority of asthma exacerbations are caused by rhinovirus. Currently the treatment of
asthma exacerbations is inadequate. Previous evidence suggests that macrolide antibiotics …

More than a billion humans worldwide are predicted to be completely deficient in the fast
skeletal muscle fiber protein α-actinin-3 owing to homozygosity for a premature stop codon …

The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I
and MDA5 in viral infection is much debated. We investigated the roles of each pattern …