Pediatric applications of Dotatate: early diagnostic and therapeutic experience

KM McElroy, LA Binkovitz, AT Trout, MR Czachowski… - Pediatric …, 2020 - Springer
In recent years, new somatostatin receptor agents (SSTRs) have become available for
diagnostic imaging and therapy in neuroendocrine tumors. The novel SSTR ligand DOTA-DPhel-…

Deposition studies of aerosol delivery by nasal cannula to infants

…, PS Adams, DJ Johnston, MR Czachowski… - Pediatric …, 2019 - Wiley Online Library
Aim Nasal cannulas are used to provide oxygen support for infants and have been considered
as a means for delivering aerosols to the lungs. To measure mucociliary clearance in the …

Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung

…, L Weber, MR Czachowski… - European …, 2016 - Eur Respiratory Soc
Airway surface liquid hyperabsorption and mucus accumulation are key elements of cystic
fibrosis lung disease that can be assessed in vivo using functional imaging methods. In this …

Quantitative imaging of airway liquid absorption in cystic fibrosis

…, RS Parker, L Weber, MR Czachowski… - European …, 2014 - Eur Respiratory Soc
New measures are needed to rapidly assess emerging treatments for cystic fibrosis (CF)
lung disease. Using an imaging approach, we evaluated the absorptive clearance of the …

Multiprobe nuclear imaging of the cystic fibrosis lung as a biomarker of therapeutic effect

…, RT Lacy, L Weber, MR Czachowski… - Journal of aerosol …, 2019 - liebertpub.com
Background: Nuclear imaging biomarkers illustrate unique aspects of lung physiology and
are useful for assessing therapeutic effects in cystic fibrosis (CF) lung disease. We have …

Use of intraoperative nuclear imaging leads to decreased anesthesia time and real-time confirmation of lesion removal

…, BKN Seynnaeve, AJ Davit III, MR Czachowski… - Journal of Pediatric …, 2018 - Elsevier
Background Lymphatic mapping to guide sentinel lymph node biopsy (SLNB) typically
requires lymphoscintigraphy prior to surgery. In young pediatric patients, this process often …

Pediatric applications of Dotatate: reply to Shulkin et al.

KM McElroy, LA Binkovitz, AT Trout, MR Czachowski… - Pediatric …, 2021 - Springer
Dear Editors, The authors of a letter to the editor [1] raise several points related to our recent
Dotatate imaging and therapy review article published in Pediatric Radiology [2]. Item 1 in …

Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Biodistribution, Mechanisms of Transduction and Imaging Application

…, N Pogodzinski, X Xu, R Yurko, MR Czachowski… - Circulation, 2018 - Am Heart Assoc
Background: Cardiac diagnostics and therapeutics are limited by lack of a specific vector
targeting the heart. Our previous work utilizing phage display identified a 12-amino acid, …

Impaired Pulmonary Function After Congenital Cardiac Surgery

…, TE Corcoran, D Weiner, MR Czachowski… - A107. PEDIATRIC …, 2017 - atsjournals.org
RATIONALE: cardiac surgery with cardiopulmonary bypass (CPB). However, the exact causes
of pulmonary impairment post-CPB remain unknown. In this study, we hypothesize that …

[HTML][HTML] Cardiac targeting peptide, a novel cardiac vector: studies in bio-distribution, imaging application, and mechanism of transduction

…, N Pogodzinski, X Xu, R Yurko, M Czachowski… - Biomolecules, 2018 - mdpi.com
Our previous work identified a 12-amino acid peptide that targets the heart, termed cardiac
targeting peptide (CTP). We now quantitatively assess the bio-distribution of CTP, show a …