LSST: from science drivers to reference design and anticipated data products
Major advances in our understanding of the universe have historically arisen from dramatic
improvements in our ability to “see.” We have developed progressively larger telescopes …
improvements in our ability to “see.” We have developed progressively larger telescopes …
Ethical leadership: A social learning perspective for construct development and testing
Leaders should be a key source of ethical guidance for employees. Yet, little empirical research
focuses on an ethical dimension of leadership. We propose social learning theory as a …
focuses on an ethical dimension of leadership. We propose social learning theory as a …
[HTML][HTML] SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
…, JL Goldstein, MS Brown - The Journal of clinical …, 2002 - Am Soc Clin Investig
SPOTLIGHT Critical review thesis. Like SREBP-1a, SREBP-2 has a long transcriptional
activation domain, but it preferentially activates cholesterol synthesis (1). SREBP-1a and SREBP-…
activation domain, but it preferentially activates cholesterol synthesis (1). SREBP-1a and SREBP-…
Regulation of the mevalonate pathway
JL Goldstein, MS Brown - Nature, 1990 - nature.com
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions,
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …
A receptor-mediated pathway for cholesterol homeostasis
MS Brown, JL Goldstein - Science, 1986 - science.org
IN 1901, AFTER STUDYING A PATIENT WITH BLACK URINE, A physician named Archibald
Garrod suggested thata single mutant gene can produce a discrete block in a biochemical …
Garrod suggested thata single mutant gene can produce a discrete block in a biochemical …
[HTML][HTML] The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
MS Brown, JL Goldstein - Cell, 1997 - cell.com
Animal cells must regulate their biosynthetic pathways so as to produce the required amounts
of end-products without risking overproduction. Such control is particularly important in …
of end-products without risking overproduction. Such control is particularly important in …
Ethical leadership: A review and future directions
ME Brown, LK Treviño - The leadership quarterly, 2006 - Elsevier
Our literature review focuses on the emerging construct of ethical leadership and compares
this construct with related concepts that share a common concern for a moral dimension of …
this construct with related concepts that share a common concern for a moral dimension of …
[HTML][HTML] Early remdesivir to prevent progression to severe Covid-19 in outpatients
…, G Oguchi, P Ryan, BU Nielsen, M Brown… - … England Journal of …, 2022 - Mass Medical Soc
Background Remdesivir improves clinical outcomes in patients hospitalized with moderate-to-severe
coronavirus disease 2019 (Covid-19). Whether the use of remdesivir in …
coronavirus disease 2019 (Covid-19). Whether the use of remdesivir in …
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
…, YK Ho, SK Basu, MS Brown - Proceedings of the …, 1979 - National Acad Sciences
Resident mouse peritoneal macrophages were shown to take up and degrade acetylated
125 I-labeled low density lipoprotein ( 125 I-acetyl-LDL) in vitro at rates that were 20-fold …
125 I-labeled low density lipoprotein ( 125 I-acetyl-LDL) in vitro at rates that were 20-fold …
Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a …
…, NC Bambakidis, K Becker, J Biller, M Brown… - Stroke, 2019 - Am Heart Assoc
Background and Purpose— The purpose of these guidelines is to provide an up-to-date
comprehensive set of recommendations in a single document for clinicians caring for adult …
comprehensive set of recommendations in a single document for clinicians caring for adult …