Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre …
…, NG Okumus, Z Onen, HJ Chang, SA Chang… - The Lancet …, 2021 - thelancet.com
Background Riociguat and phosphodiesterase-5 inhibitors (PDE5i), approved for the
treatment of pulmonary arterial hypertension (PAH), act on the same pathway via different …
treatment of pulmonary arterial hypertension (PAH), act on the same pathway via different …
RESPITE: switching to riociguat in pulmonary arterial hypertension patients with inadequate response to phosphodiesterase-5 inhibitors
…, E Grünig, CD Vizza, MK Chang… - European …, 2017 - Eur Respiratory Soc
A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals
with phosphodiesterase-5 inhibitors (PDE5i). RESPITE investigated the safety, feasibility …
with phosphodiesterase-5 inhibitors (PDE5i). RESPITE investigated the safety, feasibility …
[HTML][HTML] Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
M Nakaya, Y Xiao, X Zhou, JH Chang, M Chang… - Immunity, 2014 - cell.com
Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake
is mediated during T cell activation is poorly understood. We have shown that naive T cell …
is mediated during T cell activation is poorly understood. We have shown that naive T cell …
Immunological responses to oxidized LDL
S Hörkkö, CJ Binder, PX Shaw, MK Chang… - Free Radical Biology …, 2000 - Elsevier
Considerable evidence now points to an important role for the immune system in experimental
models of atherosclerosis. We have reviewed the growing body of evidence that oxidation …
models of atherosclerosis. We have reviewed the growing body of evidence that oxidation …
Innate and acquired immunity in atherogenesis
Traditional risk factors like hypercholesterolemia are important for atherogenesis, but it is
now apparent that the immune system also plays an important role. Uncovering the …
now apparent that the immune system also plays an important role. Uncovering the …
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL
CJ Binder, S Hörkkö, A Dewan, MK Chang, EP Kieu… - Nature medicine, 2003 - nature.com
During the progression of atherosclerosis, autoantibodies are induced to epitopes of oxidized
low-density lipoprotein (oxLDL) and active immunization of hypercholesterolemic mice …
low-density lipoprotein (oxLDL) and active immunization of hypercholesterolemic mice …
[HTML][HTML] Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
PX Shaw, S Hörkkö, MK Chang… - The Journal of …, 2000 - Am Soc Clin Investig
The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis.
Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that …
Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that …
C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: phosphorylcholine of oxidized phospholipids
MK Chang, CJ Binder, M Torzewski… - Proceedings of the …, 2002 - National Acad Sciences
C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphorylcholine
(PC) as a component of microbial capsular polysaccharide and participates in the innate …
(PC) as a component of microbial capsular polysaccharide and participates in the innate …
Novel TCF‐binding sites specify transcriptional repression by Wnt signalling
TA Blauwkamp, MV Chang, KM Cadigan - The EMBO journal, 2008 - embopress.org
Both transcriptional activation and repression have essential functions in maintaining
proper spatial and temporal control of gene expression. Although Wnt signalling is often …
proper spatial and temporal control of gene expression. Although Wnt signalling is often …
[HTML][HTML] IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
CJ Binder, K Hartvigsen, MK Chang… - The Journal of …, 2004 - Am Soc Clin Investig
… Chang was supported by a scientist development grant from the AHA. We are grateful to
Manfred Kopf for provision of the IL-5 –/– mice. We thank Gary Bradshaw, Joshua Bulgrien, …
Manfred Kopf for provision of the IL-5 –/– mice. We thank Gary Bradshaw, Joshua Bulgrien, …