Rationale: There is currently no effective pharmacological treatment for obstructive sleep
apnea (OSA). Recent investigations indicate that drugs with noradrenergic and antimuscarinic …

Rationale: Therapies for obstructive sleep apnea (OSA) could be administered on the basis
of a patient’s own phenotypic causes (“traits”) if a clinically applicable approach were …

Study Objectives Precision medicine for obstructive sleep apnea (OSA) requires noninvasive
estimates of each patient’s pathophysiological “traits.” Here, we provide the first automated …

We recently demonstrated that desipramine reduces the sleep-related loss of upper airway
dilator muscle activity and reduces pharyngeal collapsibility in healthy humans without …

A possible precision-medicine approach to treating obstructive sleep apnoea (OSA) involves
targeting ventilatory instability (elevated loop gain) using supplemental inspired oxygen in …

Rationale: Obstructive sleep apnea is a state-dependent disease. One of the key factors that
triggers upper airway collapse is decreased pharyngeal dilator muscle activity during sleep. …

Obstructive sleep apnoea (OSA) is characterised by pharyngeal obstruction occurring at
different sites. Endoscopic studies reveal that epiglottic collapse renders patients at higher risk …

Objectives: In some patients, obstructive sleep apnea (OSA) can be resolved with improvement
in pharyngeal patency by sleeping lateral rather than supine, possibly as gravitational …

Study Objectives Oral appliance therapy is an increasingly common option for treating
obstructive sleep apnea (OSA) in patients who are intolerant to continuous positive airway …

Rationale and objectives Non-invasive quantification of the severity of pharyngeal airflow
obstruction would enable recognition of obstructive versus central manifestation of sleep …