Background The relation between body weight and overall mortality remains controversial
despite considerable investigation. Methods We examined the association between body-…

Background Inflammation may be important in the pathogenesis of atherothrombosis. We
studied whether inflammation increases the risk of a first thrombotic event and whether …

Background Previous studies have examined individual dietary and lifestyle factors in relation
to type 2 diabetes, but the combined effects of these factors are largely unknown. Methods …

Insulin-like growth factor–I (IGF-I) is a mitogen for prostate epithelial cells. To investigate
associations between plasma IGF levels and prostate cancer risk, a nested case-control study …

Objective. —To assess prospectively the risk of coronary heart disease associated with
elevated plasma levels of homocyst(e)ine. Design. —Nested case-control study using …

Background Data for front-line health-care workers and risk of COVID-19 are limited. We
sought to assess risk of COVID-19 among front-line health-care workers compared with the …

The aim of this study was to evaluate the reproducibility and validity of a 61-item semiquantitative
food frequency questionnaire used in a large prospective study among women. This …

Background. The effect of postmenopausal estrogen therapy on the risk of cardiovascular
disease remains controversial. Our 1985 report in the Journal, based on four years of follow-up…

Objective. —To examine prospectively the relationship between glycemic diets, low fiber intake,
and risk of non—insulin-dependent diabetes mellitus. Desing. —Cohort study. Setting. —…

Background Interest in the antioxidant vitamin E as a possible protective nutrient against
coronary disease has intensified with the recognition that oxidized low-density lipoprotein may …