Chronic infection by Pseudomonas aeruginosa in cystic fibrosis (CF) patients is a major
contributor to progressive lung damage and is poorly treated by available antibiotic therapy. An …

Antibiotic discovery and preclinical testing are needed to combat the Pseudomonas aeruginosa
health threat. Most frequently, antibiotic efficacy is tested in models of acute respiratory …

Background High-mobility group box 1 protein (HMGB1) is an ubiquitous nuclear protein that
once released in the extracellular space acts as a Damage Associated Molecular Pattern …

Several chronic respiratory diseases are characterized by recurrent and/or persistent infections,
chronic inflammatory responses and tissue remodeling, including increased levels of …

We previously demonstrated that β-sitosterol (BSS) inhibits the expression of the chemokine
IL-8 in CF bronchial epithelial cells exposed to P. aeruginosa. In the mouse model of lung …

We previously demonstrated that β-sitosterol (BSS) inhibits the expression of the chemokine
IL-8 in CF bronchial epithelial cells exposed to P. aeruginosa. In the mouse model of lung …

The ECFS is committed to providing you with a platform to discuss your ideas with your
colleagues during this important conference which will comprise a series of symposia with invited …

Despite intensive antimicrobial and anti-inflammatory therapies, cystic fibrosis (CF) patients
are subjected to chronic infections due to opportunistic pathogens, including multidrug …

Background Patients with CF and Residual Function mutations (RFm) have often delayed
diagnosis, milder lung disease and pancreatic sufficiency, compared with homozygous for …

Stem cell homing and breast cancer metastasis are orchestrated by the chemokine stromal
cell–derived factor 1 (SDF-1) and its receptor CXCR4. Here, we report the nuclear magnetic …