User profiles for Max Borsche

Max Borsche

MD, Institute of Neurogenetics, University of Lübeck, Lübeck, Germany
Verified email at neuro.uni-luebeck.de
Cited by 1557

Parkin and PINK1 mitigate STING-induced inflammation

…, Y Li, Z Zhang, DP Narendra, H Cai, M Borsche… - Nature, 2018 - nature.com
Although serum from patients with Parkinson’s disease contains elevated levels of numerous
pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether inflammation …

[HTML][HTML] Mitochondria and Parkinson's disease: clinical, molecular, and translational aspects

M Borsche, SL Pereira, C Klein… - Journal of Parkinson's …, 2021 - content.iospress.com
Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson’s disease (PD). Initially originating from the observation …

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

M Borsche, IR König, S Delcambre, S Petrucci, A Balck… - Brain, 2020 - academic.oup.com
There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent
research in murine models suggests that parkin and PINK1 deficiency leads to impaired …

Complications of nasal and pharyngeal swabs: a relevant challenge of the COVID-19 pandemic?

B Föh, M Borsche, A Balck, S Taube… - European …, 2021 - Eur Respiratory Soc
The coronavirus disease 2019 (COVID-19) pandemic comprises approximately 50 million
confirmed cases and over 1.2 million deaths as of 10 November, 2020 [1], affecting healthcare …

One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: A model for population-based monitoring of infection risk

C Klein, M Borsche, A Balck, B Föh, J Rahmöller… - Science …, 2022 - science.org
With newly rising coronavirus disease 2019 (COVID-19) cases, important data gaps remain
on (i) long-term dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2…

[HTML][HTML] Frequency of Heterozygous Parkin (PRKN) Variants and Penetrance of Parkinson's Disease Risk Markers in the Population-Based CHRIS Cohort

…, A Raftopoulou, M Gögele, M Borsche… - Frontiers in …, 2021 - frontiersin.org
Mutations in the Parkin (PRKN) gene are the most frequent cause of autosomal recessive
early-onset Parkinson's disease (PD). Heterozygous PRKN mutation carriers might also be at …

Utility and implications of exome sequencing in early‐onset Parkinson's disease

…, H Baumann, A Balck, M Borsche… - Movement …, 2019 - Wiley Online Library
Background Although the genetic load is high in early‐onset Parkinson's disease, thorough
investigation of the genetic diagnostic yield has yet to be established. The objectives of this …

In Vivo Investigation of Glucose Metabolism in Idiopathic and PRKN‐Related Parkinson's Disease

M Borsche, A Märtens, P Hörmann… - Movement …, 2023 - Wiley Online Library
Background Alterations in mitochondrial dysfunction have been implicated in the pathogenesis
of Parkinson's disease (PD). Mitochondrial energy production is linked to glucose …

Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson's disease

…, T Lüth, S Schaake, K Wasner, J Ghelfi, M Borsche… - Brain, 2023 - academic.oup.com
Biallelic mutations in PINK1/PRKN cause recessive Parkinson’s disease. Given the established
role of PINK1/Parkin in regulating mitochondrial dynamics, we explored mitochondrial …

[HTML][HTML] Bilateral vestibulopathy in RFC1-positive CANVAS is distinctly different compared to FGF14-linked spinocerebellar ataxia 27B

M Borsche, M Thomsen, DJ Szmulewicz, B Lübbers… - Journal of …, 2023 - Springer
The recent discoveries of two new repeat expansion disorders for late-onset cerebellar ataxia
(CA), frequently accompanied by vestibulopathy and neuropathy, shed new light on ataxia …