User profiles for Max Borsche
Max BorscheMD, Institute of Neurogenetics, University of Lübeck, Lübeck, Germany Verified email at neuro.uni-luebeck.de Cited by 1557 |
Parkin and PINK1 mitigate STING-induced inflammation
…, Y Li, Z Zhang, DP Narendra, H Cai, M Borsche… - Nature, 2018 - nature.com
Although serum from patients with Parkinson’s disease contains elevated levels of numerous
pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether inflammation …
pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether inflammation …
[HTML][HTML] Mitochondria and Parkinson's disease: clinical, molecular, and translational aspects
Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson’s disease (PD). Initially originating from the observation …
monogenic and idiopathic Parkinson’s disease (PD). Initially originating from the observation …
Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent
research in murine models suggests that parkin and PINK1 deficiency leads to impaired …
research in murine models suggests that parkin and PINK1 deficiency leads to impaired …
Complications of nasal and pharyngeal swabs: a relevant challenge of the COVID-19 pandemic?
The coronavirus disease 2019 (COVID-19) pandemic comprises approximately 50 million
confirmed cases and over 1.2 million deaths as of 10 November, 2020 [1], affecting healthcare …
confirmed cases and over 1.2 million deaths as of 10 November, 2020 [1], affecting healthcare …
One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: A model for population-based monitoring of infection risk
With newly rising coronavirus disease 2019 (COVID-19) cases, important data gaps remain
on (i) long-term dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2…
on (i) long-term dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2…
[HTML][HTML] Frequency of Heterozygous Parkin (PRKN) Variants and Penetrance of Parkinson's Disease Risk Markers in the Population-Based CHRIS Cohort
Mutations in the Parkin (PRKN) gene are the most frequent cause of autosomal recessive
early-onset Parkinson's disease (PD). Heterozygous PRKN mutation carriers might also be at …
early-onset Parkinson's disease (PD). Heterozygous PRKN mutation carriers might also be at …
Utility and implications of exome sequencing in early‐onset Parkinson's disease
Background Although the genetic load is high in early‐onset Parkinson's disease, thorough
investigation of the genetic diagnostic yield has yet to be established. The objectives of this …
investigation of the genetic diagnostic yield has yet to be established. The objectives of this …
In Vivo Investigation of Glucose Metabolism in Idiopathic and PRKN‐Related Parkinson's Disease
M Borsche, A Märtens, P Hörmann… - Movement …, 2023 - Wiley Online Library
Background Alterations in mitochondrial dysfunction have been implicated in the pathogenesis
of Parkinson's disease (PD). Mitochondrial energy production is linked to glucose …
of Parkinson's disease (PD). Mitochondrial energy production is linked to glucose …
Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson's disease
…, T Lüth, S Schaake, K Wasner, J Ghelfi, M Borsche… - Brain, 2023 - academic.oup.com
Biallelic mutations in PINK1/PRKN cause recessive Parkinson’s disease. Given the established
role of PINK1/Parkin in regulating mitochondrial dynamics, we explored mitochondrial …
role of PINK1/Parkin in regulating mitochondrial dynamics, we explored mitochondrial …
[HTML][HTML] Bilateral vestibulopathy in RFC1-positive CANVAS is distinctly different compared to FGF14-linked spinocerebellar ataxia 27B
M Borsche, M Thomsen, DJ Szmulewicz, B Lübbers… - Journal of …, 2023 - Springer
The recent discoveries of two new repeat expansion disorders for late-onset cerebellar ataxia
(CA), frequently accompanied by vestibulopathy and neuropathy, shed new light on ataxia …
(CA), frequently accompanied by vestibulopathy and neuropathy, shed new light on ataxia …