There is accumulating evidence that T‐cell‐mediated dominant control of self‐reactive T‐cells
contributes to the maintenance of immunologic self‐tolerance and its alteration can cause …

Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal
unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules. When CD4+ …

Elimination of CD25+ T cells, which constitute 5-10% of peripheral CD4+ T cells in normal
naive mice, leads to spontaneous development of various autoimmune diseases. These …

Neonatal thymectomy (NTx), especially around day 3 after birth, causes various organ-specific
autoimmune diseases in mice. This report shows that: (a) T cells expressing the …

This paper shows that elimination of a small subpopulation of peripheral T cells can elicit
activation/expansion of self-reactive T cells from the remaining T cells and produce a wide …

ONO-5046, N-[2-[4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino]benzoyl] aminoacetic
acid, competitively inhibited human neutrophil elastase (IC 50 =0.044 μM, Ki = 0.2μM). It also …

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology;
however, apoptosis of lung alveolar epithelial cells plays a role in disease progression. This …

Regulatory T cells (Tregs) are a specific subset of T lymphocytes that regulate the function of
other subsets of lymphocytes. Contradictory results have been reported regarding the role …

Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute exacerbation
of idiopathic pulmonary fibrosis is associated with high mortality. Excessive apoptosis of …

The process of discovering a series of N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acid
analogs is presented since these compounds represent a new class of potent, selective, and …