Severe influenza infection has no effective treatment available. One of the key barriers to
developing host-directed therapy is a lack of reliable prognostic factors needed to guide such …

Cirrhosis likely shares common pathophysiological pathways despite arising from a variety
of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, …

Background Protective helmets may reduce the risk of death and head injury in motorcycle
collisions. However, there remains a large gap in knowledge regarding the effectiveness of …

Predicting the severity of COVID-19 remains an unmet medical need. Our objective was to
develop a blood-based host-gene-expression classifier for the severity of viral infections and …

Knowledge of the mechanisms underpinning the development of protective immunity
conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus …

Host response biomarkers can accurately distinguish between influenza and bacterial
infection. However, published biomarkers require the measurement of many genes, thereby …

Background Inter-individual variability during sepsis limits appropriate triage of patients.
Identifying, at first clinical presentation, gene expression signatures that predict subsequent …

Purpose Robust biomarkers that predict disease outcomes amongst COVID-19 patients are
necessary for both patient triage and resource prioritisation. Numerous candidate …

Brewers’ spent grains (BSGs) are the most important by-product of the brewing industry and
are rich in protein and fiber. However, abundant amounts of BSGs are discarded annually …

The relative contribution of a theory-based intervention to modify high-risk behaviors in training
programs is a major priority that remains an open question. Here, we tested whether the …