Background Some patients with asthma have frequent exacerbations and persistent airflow
obstruction despite treatment with inhaled glucocorticoids and long-acting beta-agonists (…

… Chronic hyperplastic eosinophilic rhinosinusitis does not respond to antibiotics and is marked
by a preponderance of eosinophils and mixed mononuclear cells, with a relative paucity of …

Objective. Intranasal corticosteroids are used widely for the treatment of allergic rhinitis
because they are effective and well tolerated. However, their potential to suppress growth of …

Background Results from phase III clinical trials in adults and phase II clinical trials in
children and adolescents demonstrate that tiotropium is an effective treatment when added to …

We present results from the first phase III trial of once-daily tiotropium add-on to inhaled
corticosteroids (ICS) plus one or more controller therapies in adolescents with severe …

Background Many patients with asthma remain symptomatic despite treatment with inhaled
corticosteroids (ICS) with or without long-acting β 2 -agonists (LABAs). Tiotropium add-on to …

Introduction Tiotropium, a once-daily long-acting anticholinergic agent, has been shown to
be an efficacious and safe add-on treatment for adults with symptomatic asthma, despite …

Background: Topical nasal corticosteroids have become a mainstay of treatment for the
symptoms of seasonal allergic rhinitis (SAR). It is likely that topical corticosteroids, by blocking an …

Objective: To determine whether inhaled fluticasone propionate has long-term effects on growth
in children with persistent asthma. Study Design: In a double-blind, randomized, parallel-…

Background Few studies have assessed the safety and efficacy of potential asthma medications
in children younger than 5 years. We descriptively assessed the safety and efficacy of …