Background. Highly pathogenic avian H5N1 influenza viruses preferentially infect alveolar
type II pneumocytes in human lung. However, it is unknown whether this cellular tropism …

Middle East respiratory syndrome coronavirus (MERS-CoV) has alerted the public health
systems by causing lethal respiratory disease in 54 of 114 confirmed human cases as of …

Background Surgical treatment of patients with limited metastatic lesions from non-small cell
lung cancer (NSCLC) remains controversial; however, reports suggest that a subset of …

We investigated in a unique setup of animal models and a human lung explant culture
biological properties, including zoonotic potential, of a representative 2016 highly pathogenic …

The severity and lethality of influenza A virus (IAV) infections is frequently aggravated by
secondary bacterial pneumonia. However, the mechanisms in human lung tissue that provoke …

Streptococcus pneumoniae (S.pn.) is the most common bacterial pathogen causing community
acquired pneumonia. The pore-forming toxin pneumolysin (PLY) is the major virulence …

Early immune responses to Mycobacterium tuberculosis (Mtb) invasion of the human lung
play a decisive role in the outcome of infection, leading to either rapid clearance of the …

Mechanisms of epithelial renewal in the alveolar compartment remain incompletely
understood. To this end, we aimed to characterize alveolar progenitors. Single-cell RNA-sequencing …

The lung represents an important target for the toxic effects of chemicals. Many of the chemicals
require enzymatic activation to exert their adverse effects, which is mostly catalysed by …

Single-cell ribonucleic acid sequencing is becoming widely employed to study biological
processes at a novel resolution depth. The ability to analyse transcriptomes of multiple …