New Findings What is the topic of this review? This review addresses the contribution of the
altered gut microbiome to uraemic syndrome, with specific reference to gut microbiome‐…

Results Plasma levels of IL-1β, IL-1RA, IL-6, TNF-α, hs-CRP, and fibrinogen were higher
among participants with lower levels of eGFR. Inflammation score was higher among those with …

Epigenetic modifications are important in the normal functioning of the cell, from regulating
dynamic expression of essential genes and associated proteins to repressing those that are …

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies
have examined T2DM using genome-wide association approaches in this ethnicity. The aim …

A genome-wide association study was performed using the Affymetrix 6.0 chip to identify
genes associated with diabetic nephropathy in African Americans. Association analysis was …

Background Epigenetic mechanisms may be important in the progression of chronic kidney
disease (CKD). Methods We studied the genome-wide DNA methylation pattern associated …

Background Micro RNA s (mi RNA s) are noncoding RNA molecules that play important
roles in the pathogenesis of various kidney diseases. We investigated whether patients with …

The safety and efficacy of spironolactone is uncertain in end-stage renal disease. We randomized
129 maintenance hemodialysis patients to placebo (n=51) or spironolactone 12.5 mg (…

Multiple studies have identified FTO gene variants associated with measures of adiposity in
European-derived populations. The objective of the study was to determine whether FTO …

Recent genome‐wide association studies (GWAS) have identified multiple novel loci associated
with obesity in Europeans but results in other ethnicities are less convincing. Here, we …