Imidazolidin-4-one derivatives of primaquine were synthesized as potential double prodrugs
of the parent drug. The title compounds inhibit the development of the sporogonic cycle of …

The synthesis of imidazolidin-4-one derivatives of primaquine as potential antimalarial agents
is described. The target compounds were synthesized in three steps: (i) condensation of (±…

Objetivos: A equipa da Unidade de Saúde Familiar (USF) S. Julião verificou que o consentimento
informado não era obtido nos procedimentos de planeamento familiar–colocação de …

Gemcitabine proven efficiency against a wide range of solid tumors and undergoes
deamination to its inactive uridine metabolite, which underlies its low bioavailability, and tumour …

Small, single-celled planktonic cyanobacteria are ubiquitous in the world’s oceans yet tend
not to be perceived as secondary metabolite-rich organisms. Here we report the isolation …

Introduction and purpose The impact of hypocapnia in the prognosis of cardiogenic acute
pulmonary edema (CAPE) has not been sufficiently studied. The aim of this study was to …

Amino acid-derived gemini surfactants arise as a potentially good alternative to the more
conventional lipid and synthetic catanionic systems in view of their enhanced interfacial …

Double-chained surfactants with potential biocompatibility have been prepared in high
yields by lysine acylation with four natural saturated fatty acids (C 6 to C 12 ) and with cis-undec-5…

Aqueous surfactant/polymer mixtures form colloidal structures of great fundamental interest
and practical relevance, such as nanostructured hydrogels for biomedical and …

Sol–gel molecularly imprinted materials (MIMs) are traditionally obtained by grinding and
sieving of a monolith formed by bulk polymerization. However, this process has several …