IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells

SN Karagiannis, MG Bracher, J Hunt… - The Journal of …, 2007 - journals.aai.org
Abs have a paramount place in the treatment of certain, mainly lymphoid, malignancies,
although tumors of nonhemopoietic origin have proved more refractory ones. We have …

Activity of human monocytes in IgE antibody‐dependent surveillance and killing of ovarian tumor cells

…, N East, F Burke, S Riffard, MG Bracher… - European journal of …, 2003 - Wiley Online Library
We have previously shown that a chimeric IgE antibody against the folic acid receptor (MOv18
IgE) inhibits tumor growth in a SCID mouse model of ovarian carcinoma. MOv18 IgE gave …

Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells

SN Karagiannis, MG Bracher, RL Beavil… - Cancer Immunology …, 2008 - Springer
Antibodies directed against tumor-associated antigens are emerging as effective treatments
for a number of cancers, although the mechanism(s) of action for some are unclear and still …

[HTML][HTML] Qualitative concept elicitation and cognitive debriefing interviews of symptoms, impacts and selected customized PROMIS® Short Forms: a study in patients …

…, W Neill, S Tatlock, WH Chen, MG Bracher… - Journal of Patient …, 2023 - Springer
Background Sleep disturbance, pain, and fatigue are key symptoms/impacts of axial
spondyloarthritis (axSpA). Three customized Patient-Reported Outcomes Measurement Information …

[HTML][HTML] Attenuation of IgE affinity for FcϵRI radically reduces the allergic response in vitro and in vivo

J Hunt, MG Bracher, J Shi, S Fleury… - Journal of biological …, 2008 - ASBMB
The high affinity of IgE for its receptor, FcϵRI (K a ∼ 10 10 m –1 ), is responsible for the
persistence of mast cell sensitization. Cross-linking of FcϵRI-bound IgE by multivalent allergen …

[HTML][HTML] Meaningful score changes for SF-36v2, FACIT-fatigue, and RASIQ in rheumatoid arthritis

…, X Lin, M Kosinski, JB Bjorner, MG Bracher… - Journal of Patient …, 2024 - Springer
Background Interpretation thresholds for patient-reported outcome (PRO) scores are of crucial
importance, particularly when interpreting treatment benefit. This study was designed to …

[PDF][PDF] IgE-Antibody-Dependent Immunotherapy of

…, RL Beavil, AJ Beavil, SN Karagiannis, MG Bracher… - J Immunol, 2007 - academia.edu
Abs have a paramount place in the treatment of certain, mainly lymphoid, malignancies,
although tumors of nonhemopoietic origin have proved more refractory ones. We have …

Economic burden associated with clinical management of COVID-19–A literature review

E Lu, E Han, AE Heyes, J Mauskopf, MG Bracher… - 2021 - Eur Respiratory Soc
Background: COVID-19, due to its deadly nature and rapid spread, is causing significant
global economic burden. Aim: To summarize emerging data on direct costs associated with …

Three-colour flow cytometric method to measure antibody-dependent tumour cell killing by cytotoxicity and phagocytosis

M Bracher, HJ Gould, BJ Sutton, D Dombrowicz… - Journal of …, 2007 - Elsevier
We have developed a three-colour flow cytometric method to assay the contributions of
cytotoxicity and phagocytosis to antibody-dependent cell-mediated tumour cell killing. In this …

[HTML][HTML] Development, psychometric evaluation and cognitive debriefing of the rheumatoid arthritis symptom and impact questionnaire (RASIQ)

B Becker, M Bracher, D Chauhan… - Journal of Patient …, 2021 - Springer
Background Rheumatoid arthritis (RA) is a chronic inflammatory disease often associated
with persistent pain. There is a need for a patient-reported outcome measure (PROM) that is …