CD4 is crucial for antigen-driven helper T cell signaling and is used as receptor by the human
immunodeficiency virus (HIV). The HIV early protein Nef causes a loss of CD4 from cell …

Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes,
heart disease, and hypertension. We used a dense whole-genome scan of DNA samples …

Background We studied Dicer and Drosha, components of the RNA-interference machinery,
in ovarian cancer. Methods We measured messenger RNA (mRNA) levels of Dicer and …

Lung cancer is the leading cause of death from cancer in the US and the world 1 . The high
mortality rate (80–85% within 5 years) results, in part, from a lack of effective tools to …

We have shown that smoking impacts bronchial airway gene expression and that heterogeneity
in this response associates with smoking-related disease risk. In this study, we sought to …

Estrogen, progesterone, and HER2 receptor-negative triple-negative breast cancers encompass
the most clinically challenging subtype for which targeted therapeutics are lacking. We …

Phosphate starvation induces the transcription of several genes involved in phosphate
metabolism in the budding yeast Saccharomyces cerevisiae. The signal transduction pathway …

Neoadjuvant chemotherapy for breast cancer allows individual tumor response to be
assessed depending on molecular subtype, and to judge the impact of response to therapy on …

We review here the recently emerging relationship between epithelial-mesenchymal transition
(EMT) and breast cancer stem cells (BCSC), and provide analyses of published data on …

Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and
likely includes a subgroup that is biologically comparable to asthma. Studying asthma-…