[HTML][HTML] Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

…, A Schapfl, M Schaber, R Hilbe, M Nairz… - European …, 2021 - Eur Respiratory Soc
Background After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of
survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary …

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications

I Theurl, E Aigner, M Theurl, M Nairz… - Blood, The Journal …, 2009 - ashpublications.org
The anemia of chronic disease (ACD) is characterized by macrophage iron retention induced
by cytokines and the master regulator hepcidin. Hepcidin controls cellular iron efflux on …

The struggle for iron–a metal at the host–pathogen interface

M Nairz, A Schroll, T Sonnweber… - Cellular …, 2010 - Wiley Online Library
Iron holds a central position at the host–pathogen interface because mammalian and
microbial cells have an essential demand for the metal, which is required for many metabolic …

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

I Theurl, I Hilgendorf, M Nairz, P Tymoszuk… - Nature medicine, 2016 - nature.com
Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen
transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with …

Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2

…, M Borkovec, P Hufnagl, M Nairz… - Science translational …, 2020 - science.org
Superspreading events shaped the coronavirus disease 2019 (COVID-19) pandemic, and
their rapid identification and containment are essential for disease control. Here, we provide a …

[HTML][HTML] Iron in infection and immunity

M Nairz, G Weiss - Molecular Aspects of Medicine, 2020 - Elsevier
Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron to …

[HTML][HTML] Iron at the interface of immunity and infection

M Nairz, D Haschka, E Demetz, G Weiss - Frontiers in pharmacology, 2014 - frontiersin.org
Both, mammalian cells and microbes have an essential need for iron, which is required for
many metabolic processes and for microbial pathogenicity. In addition, cross-regulatory …

Faecal calprotectin indicates intestinal inflammation in COVID-19

…, F Grabherr, L Mayr, J Schwaerzler, M Nairz… - Gut, 2020 - gut.bmj.com
GI symptoms such as diarrhoea, nausea and vomiting are frequent coronavirus disease (COVID-19)
symptoms and affect up to 28% of patients. 1–5 The pathophysiology of COVID-19-…

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

GF Weber, BG Chousterman, S He, AM Fenn, M Nairz… - Science, 2015 - science.org
Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host
reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a …

Autocrine formation of hepcidin induces iron retention in human monocytes

…, M Theurl, M Seifert, S Mair, M Nairz… - Blood, The Journal …, 2008 - ashpublications.org
Hepcidin, a master regulator of iron homeostasis, is produced in small amounts by inflammatory
monocytes/macrophages. Chronic immune activation leads to iron retention within …