User profiles for M.R. Jonker
 | Marnix JonkerVerified email at umcg.nl Cited by 2304 |
A cellular census of human lungs identifies novel cell states in health and in asthma
Human lungs enable efficient gas exchange and form an interface with the environment, which
depends on mucosal immunity for protection against infectious agents. Tightly controlled …
depends on mucosal immunity for protection against infectious agents. Tightly controlled …
[HTML][HTML] Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β1 Is Increased in Chronic Obstructive Pulmonary Disease
Background Chronic obstructive pulmonary disease (COPD) is characterized by abnormal
extracellular matrix (ECM) turnover. Recently, activation of the WNT/β-catenin pathway has …
extracellular matrix (ECM) turnover. Recently, activation of the WNT/β-catenin pathway has …
Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue
Chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive
pulmonary disease (COPD) are associated with changes in extracellular matrix (ECM) …
pulmonary disease (COPD) are associated with changes in extracellular matrix (ECM) …
A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD
…, M van den Berge, DS Postma, MR Jonker… - Thorax, 2015 - thorax.bmj.com
Background Chronic obstructive pulmonary disease (COPD) is a progressive, incurable lung
disease characterised by abnormal tissue repair causing emphysema and small airways …
disease characterised by abnormal tissue repair causing emphysema and small airways …
House dust mite‐induced calcium signaling instigates epithelial barrier dysfunction and CCL 20 production
… MR Jonker cultured PBECs and performed the calcium influx and BAPTA experiments in
these cells. N. Kliphuis performed the culture and additional experiments in PBECs. …
these cells. N. Kliphuis performed the culture and additional experiments in PBECs. …
Altered expression of the Smad signalling pathway: implications for COPD pathogenesis
A Zandvoort, DS Postma, MR Jonker… - European …, 2006 - Eur Respiratory Soc
Pulmonary emphysema, as a feature of chronic obstructive pulmonary disease (COPD), is
characterised by destruction of alveolar tissue. The present authors previously demonstrated …
characterised by destruction of alveolar tissue. The present authors previously demonstrated …
Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD
…, HG de Bruin, R Dennebos, MR Jonker… - European …, 2016 - Eur Respiratory Soc
Wingless/integrase-1 (WNT) signalling is associated with lung inflammation and repair, but
its role in chronic obstructive pulmonary disease (COPD) pathogenesis is unclear. We …
its role in chronic obstructive pulmonary disease (COPD) pathogenesis is unclear. We …
[HTML][HTML] Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium
RF Hoffmann, MR Jonker, SM Brandenburg… - Scientific reports, 2019 - nature.com
COPD is characterized by chronic lung inflammation and irreversible lung tissue damage.
Inhaled noxious gases, including cigarette smoke, are the major risk factor for COPD. Inhaled …
Inhaled noxious gases, including cigarette smoke, are the major risk factor for COPD. Inhaled …
Periostin: contributor to abnormal airway epithelial function in asthma?
Periostin (POSTN) may serve as a biomarker for Type-2 mediated eosinophilic airway
inflammation in asthma. We hypothesised that a Type-2 cytokine, interleukin (IL)-13, induces …
inflammation in asthma. We hypothesised that a Type-2 cytokine, interleukin (IL)-13, induces …
[HTML][HTML] Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD
A Zandvoort, DS Postma, MR Jonker, JA Noordhoek… - Respiratory …, 2008 - Springer
Background Chronic Obstructive Pulmonary Disease (COPD) is characterized by defective
extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking. Fibroblasts …
extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking. Fibroblasts …