Pharmacology and pharmacokinetics of minoxidil

DT Lowenthal, MB Affrime - Journal of cardiovascular …, 1980 - journals.lww.com
Minoxidil is a potent oral vasodilator acting on the arteriolar side of the circulation. Reflex
tachycardia and sodium retention are consequences of increased sympathetic activity. Its …

Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration.

…, K de Bruin, DL Cutler, MB Affrime… - … (Baltimore, Md.: 1950 …, 1997 - journals.aai.org
To determine the effects of IL-10 on cytokine and granulocyte responses during endotoxemia,
two groups of eight healthy male volunteers were challenged with endotoxin (4 ng/kg) on …

Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia

…, M Levi, DL Cutler, MB Affrime… - Blood, The Journal …, 1997 - ashpublications.org
Interleukin-10 (IL-10) has been found to inhibit lipopolysaccharide (LPS)-induced tissue
factor expression by monocytes in vitro. To determine the effects of IL-10 on LPS-induced …

Pharmacodynamics of subcutaneous recombinant human interleukin‐10 in healthy volunteers

…, E Radwanski, J Gallo, MB Affrime… - Clinical …, 1997 - Wiley Online Library
Interleukin‐10 inhibits T‐lymphocyte activation and proliferation and lipopolysaccharide‐induced
monocyte production of proinflammatory cytokines. Fifty‐four healthy volunteers …

Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers

…, MG Sturgill, L Clarke, RP Cody, MB Affrime… - 1996 - ashpublications.org
Normal volunteers received single doses of recombinant human interleukin-10 (rhIL-10; n =
6 per group) or placebo (n = 3 per group) by intravenous injection to characterize …

Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor ezetimibe and simvastatin

…, DL Cutler, VK Batra, MB Affrime - British journal of …, 2002 - Wiley Online Library
Aims The primary aims of these two single‐centre, randomized, evaluator‐blind, placebo/positive‐controlled,
parallel‐group studies were to evaluate the potential for pharmacodynamic …

In vivo effects of interleukin‐10 on human cytochrome P450 activity

JC Gorski, SD Hall, P Becker, MB Affrime… - Clinical …, 2000 - Wiley Online Library
Background Injection of lipopolysaccharide into human volunteers leads to an increase in
serum interleukin‐1β, interleukin‐6, and tumor necrosis factor‐α and a significant decrease in …

Safety and tolerability of once-daily mometasone furoate aqueous nasal spray in children

MD Brannan, JM Herron, MB Affrime - Clinical therapeutics, 1997 - Elsevier
Sensitive and reproducible assessments of hypothalamic-pituitary-adrenal (HPA) axis
function were used to assess the systemic exposure and tolerability of mometasone furoate …

Bioavailability and metabolism of mometasone furoate following administration by metered‐dose and dry‐powder inhalers in healthy human volunteers

MB Affrime, F Cuss, D Padhi, M Wirth… - The Journal of …, 2000 - Wiley Online Library
These studies were conducted to assess the systemic bioavailability of mometasone furoate
(MF) administered by both the dry‐powder inhaler (DPI) and the metered‐dose inhaler with …

Excretion of loratadine in human breast milk

J Hilbert, E Radwanski, MB Affrime… - The Journal of …, 1988 - Wiley Online Library
The excretion of loratadine, a new nonsedating antihistamine, into human breast milk was
studied in six lactating nonpregnant volunteers. Each volunteer received one 40‐mg …