Objective: A relative hyperadrenergic tone related to abnormalities of the autonomic nervous
system is suspected in the mechanisms of sudden death. Therefore, we assessed the role …

Intima-media thickness (IMT) is increasingly used as a surrogate end point of vascular outcomes
in clinical trials aimed at determining the success of interventions that lower risk factors …

Background— Elastic artery stiffness, a result of arterial aging, is an independent indicator
of cardiovascular risk. The aim of the present longitudinal study was to compare the …

… Stratification of the population by baseline age (≤35 years and >35 years), baseline smoking
status, baseline body-mass index classes (<25 kg/m 2 , 25–30 kg/m 2 , and >30 kg/m 2 ), …

Objective: To assess whether the severity of asthma is associated with sensitisation to
airborne moulds rather than to other seasonal or perennial allergens. Design: Multicentre …

Background & Aims The risk of infection associated with tumor necrosis factor antagonists (anti-TNF)
and thiopurines (combination therapy) is uncertain. We assessed the risk of serious …

Rationale: Increased risk for cardiovascular morbidity and mortality has been related to both
lung function impairment and metabolic syndrome. Data on the relationship between lung …

Importance An increased risk of lymphoma has been reported among patients receiving
thiopurines for inflammatory bowel disease (IBD). The risk of lymphoma associated with anti–…

Recent studies have shown that individuals with shorter telomeres present a higher
prevalence of arterial lesions and higher risk of cardiovascular disease mortality. As a group, …

Background Although women with severe non-allergic asthma may represent a substantial
proportion of adults with asthma in clinical practice, gender differences in the incidence of …