User profiles for M. Wielscher
Matthias WielscherSenior Researcher, Medical University of Vienna Verified email at meduniwien.ac.at Cited by 3671 |
The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
[HTML][HTML] Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary …
…, V Vitart, MR Brown, M Wielscher, M Imboden… - Nature …, 2023 - nature.com
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung …
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
…, A Campbell, DJ Porteous, MR Jarvelin, M Wielscher… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association discovery …
and is the third leading cause of death globally. Through genome-wide association discovery …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
…, BC Lehne, B Kühnel, WR Scott, M Wielscher… - Nature …, 2022 - nature.com
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 …
[HTML][HTML] Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies
Background Epigenetic variations in peripheral blood have potential as biomarkers for disease.
This systematic review assesses the association of lung function and chronic obstructive …
This systematic review assesses the association of lung function and chronic obstructive …
[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
[HTML][HTML] Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
…, RC Huang, DA van der Plaat, M Wielscher… - Nature …, 2019 - nature.com
Birthweight is associated with health outcomes across the life course, DNA methylation may
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …
[HTML][HTML] Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study
…, T Doulgeraki, MD Whitaker, M Wielscher… - The Lancet …, 2021 - thelancet.com
Background Most uterine cervical high-risk human papillomavirus (HPV) infections are
transient, with only a small fraction developing into cervical cancer. Family aggregation studies …
transient, with only a small fraction developing into cervical cancer. Family aggregation studies …
[HTML][HTML] Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
…, BH Smith, MR Jarvelin, M Wielscher… - The Lancet …, 2020 - thelancet.com
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …
but the individual variants that have been identified have small effects. We hypothesised that …