User profiles for M. Tortorici

M. Alejandra Tortorici

University of Washington/Institute Pasteur
Verified email at uw.edu
Cited by 25653

Effects of hypothermia on drug disposition, metabolism, and response: a focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system

MA Tortorici, PM Kochanek, SM Poloyac - Critical care medicine, 2007 - journals.lww.com
Objectives: Therapeutic hypothermia has been shown to decrease neurologic damage in
patients experiencing out-of-hospital cardiac arrest. In addition to being treated with …

[PDF][PDF] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein

AC Walls, YJ Park, MA Tortorici, A Wall, AT McGuire… - Cell, 2020 - cell.com
The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths.
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…

[HTML][HTML] Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …

[PDF][PDF] Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

…, AS Dingens, MJ Navarro, JE Bowen, MA Tortorici… - cell, 2020 - cell.com
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …

[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

L Piccoli, YJ Park, MA Tortorici, N Czudnochowski… - Cell, 2020 - cell.com
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2
infection is crucial for understanding immune protection and identifying targets for …

[HTML][HTML] Sensitivity of SARS-CoV-2 B. 1.1. 7 to mRNA vaccine-elicited antibodies

…, D Pinto, C Silacci-Fregni, S Bianchi, MA Tortorici… - Nature, 2021 - nature.com
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded
in some areas by the higher transmission potential of the B.1.1.7 variant 1 , which has …

Rotavirus genome replication and morphogenesis: role of the viroplasm

JT Patton, LS Silvestri, MA Tortorici… - … : entry, assembly and …, 2006 - Springer
The rotaviruses, members of the family Reoviridae, are icosahedral triple-layered viruses with
genomes consisting of 11 segments of double-stranded (ds)RNA. A characteristic feature …

SARS-CoV-2 immune evasion by the B. 1.427/B. 1.429 variant of concern

…, A De Marco, A Chen, AC Walls, J Di Iulio, MA Tortorici… - Science, 2021 - science.org
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …

Clinical pharmacology of axitinib

Y Chen, MA Tortorici, M Garrett, B Hee… - Clinical …, 2013 - Springer
… The outcome of the simulation was supported in clinical studies in which co-administration
of paclitaxel (90 mg/m 2 weekly or 200 mg/m 2 every 3 weeks) with axitinib in 18 cancer …

[HTML][HTML] SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

…, I Zhang, AS Dingens, JE Bowen, MA Tortorici… - Nature, 2021 - nature.com
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape 1 , 2 – 3 , have
activity against diverse sarbecoviruses 4 , 5 , 6 – 7 , and be highly protective through viral …