Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …

Adoptive cellular immunotherapy ( ACT ) is a potentially curative therapy for patients with
advanced cancer. Eradication of tumor in mouse models and humans correlates with both a …

… Address correspondence to: Madhusudhanan Sukumar, Center for … Tran, and M. Rao for
critical review of the manuscript; A. … Goldstein and M. Malik for catalyzing interactions with …

Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based
immunotherapies. Here we perturbed genes in human melanoma cells to mimic loss-of-function …

Highlights • Memory T cells have quiescent metabolism. • Activation of T cells triggers both
glycolysis and oxidative phosphorylation. • Elevated T cell metabolic activity is necessary at …

… V m (refs 18, 19), we first investigated whether increased V m … To this end we tested whether
modulation of V m by other … gramicidin, which increases V m by forming pores in the plasma …

The antimicrobial and antioxidant effects of different spice extracts in raw chicken meat
during storage for 15 days at 4 C were studied. Raw chicken meat was treated with BHT (positive …

INTRODUCTION Cancers persist and progress despite the presence of tumor-infiltrating
lymphocytes (TILs). A paradox of tumor immunology is that tumor antigen–specific TILs are …

Th17 cells have been described as short lived, but this view is at odds with their capacity to
trigger protracted damage to normal and transformed tissues. We report that Th17 cells, …

Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in
complete regression of advanced cancer in some patients, but the efficacy of this potentially …