Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as
potential chemotherapeutic targets. To provide a framework for understanding these recent …

Poly(ADP-ribose) polymerase-1 (PARP-1) plays a primary role in the process of poly(ADP-ribosyl)ation.
This posttranslational modification of nuclear proteins is activated in response to …

The seemingly static architecture of interphase and mitotic chromatin betrays an otherwise
elegantly dynamic entity capable of remodelling itself to facilitate DNA replication, transcription…

… In brief, antibodies were diluted at the indicated concentration in 0.1 M Tris buffer, pH 9.4,
and plates incubated for a week at 4 C. After washing the plates, CD4 + T cells were added at …

Background Self-management interventions improve various outcomes for many chronic
diseases. The definite place of self-management in the care of chronic obstructive pulmonary …

Loss of pluripotency is a gradual event whose initiating factors are largely unknown. Here we
report the earliest metabolic changes induced during the first hours of differentiation. High-…

… smaller (8 m to 10 m) improvements after the training program in the 6-minute walking
distance at 3 months than usually reported after rehabilitation in COPD (48 m [CI, 31 m to 65 m]). …

Nebulized budesonide has been used successfully to treat acute asthma exacerbation, and
we hypothesized that it could also be effective for exacerbations of chronic obstructive …

PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We
show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in …

The aim of the present study was to assess the long-term impact on hospitalisation of a self-management
programme for chronic obstructive pulmonary disease (COPD) patients. A …