[HTML][HTML] The global one health paradigm: challenges and opportunities for tackling infectious diseases at the human, animal, and environment interface in low …
…, J Dupouy-Camet, MJ Newport… - PLoS neglected …, 2014 - journals.plos.org
Zoonotic infectious diseases have been an important concern to humankind for more than
10,000 years. Today, approximately 75% of newly emerging infectious diseases (EIDs) are …
10,000 years. Today, approximately 75% of newly emerging infectious diseases (EIDs) are …
Podoconiosis: non-infectious geochemical elephantiasis
This article reviews peer-reviewed publications and book chapters on the history,
epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (…
epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (…
[HTML][HTML] A mutation in the interferon-γ–receptor gene and susceptibility to mycobacterial infection
MJ Newport, CM Huxley, S Huston… - … England Journal of …, 1996 - Mass Medical Soc
Background Genetic differences in immune responses may affect susceptibility to mycobacterial
infection, but no specific genes have been implicated in humans. We studied four …
infection, but no specific genes have been implicated in humans. We studied four …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
…, A Compston, D Conway, M Jallow, M Newport… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …
to more common diseases than any other region of the human genome, including almost …
[HTML][HTML] Interferon-γ–receptor deficiency in an infant with fatal bacille Calmette–Guérin infection
… Patrick Revy, M.Sc., … Melanie Newport, MD, Ph.D., … One month later, a mycobacterium
species was cultured from the lungs and bone marrow and identified as M. bovis BCG strain. …
species was cultured from the lungs and bone marrow and identified as M. bovis BCG strain. …
Clinical features of dominant and recessive interferon γ receptor 1 deficiencies
…, R Baretto, SD Rosenzweig, M Newport, M Levin… - The Lancet, 2004 - thelancet.com
Background Interferon γ receptor 1 (IFNγ R1) deficiency is a primary immunodeficiency with
allelic dominant and recessive mutations characterised clinically by severe infections with …
allelic dominant and recessive mutations characterised clinically by severe infections with …
Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guerin vaccination
…, P Aaby, KPWJ McAdam, MJ Newport - The Journal of …, 1999 - journals.aai.org
… In parallel, we studied the response to intracellular Ags represented by a killed M. tuberculosis
preparation (K-MTB). Table I shows that infants vaccinated at birth or at 2 mo of age had …
preparation (K-MTB). Table I shows that infants vaccinated at birth or at 2 mo of age had …
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11. 2
…, D Kwiatkowski, PE Fine, PC Hill, M Newport… - Nature …, 2010 - nature.com
… loci for a given infectious disease, and the M. tuberculosis genome displays substantial
variation across … We thank M. McCarthy and C. Khor for critical assessment of the manuscript. …
variation across … We thank M. McCarthy and C. Khor for critical assessment of the manuscript. …
[HTML][HTML] Global epidemiology of podoconiosis: a systematic review
Background Podoconiosis is one of the few diseases that could potentially be eliminated
within one generation. Nonetheless, the global distribution of the disease remains largely …
within one generation. Nonetheless, the global distribution of the disease remains largely …
Influence of Mycobacterium bovis bacillus Calmette-Guerin on antibody and cytokine responses to human neonatal vaccination
…, K Fielding, M Sanneh, M Kidd, MJ Newport… - The Journal of …, 2002 - journals.aai.org
The immaturity of the immune system increases the susceptibility of young infants to infectious
diseases and prevents the induction of protective immune responses by vaccines. We …
diseases and prevents the induction of protective immune responses by vaccines. We …