Priming of the neutrophil respiratory burst: role in host defense and inflammation

…, JC Marie, MA GougerotPocidalo… - Immunological …, 2016 - Wiley Online Library
M). The priming agents alone induce either a very weak or no response, but … M fMLF), but
activate ROS production at higher concentrations 33-38. We have always used fMLF (>10 −7 M

[HTML][HTML] p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

…, PMC Dang, MA Gougerot-Pocidalo… - … & molecular medicine, 2009 - nature.com
Phagocytes such as neutrophils play a vital role in host defense against microbial pathogens.
The anti-microbial function of neutrophils is based on the production of superoxide anion (…

Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane

…, PMC Dang, MA Gougerot-Pocidalo - Seminars in …, 2008 - Springer
Neutrophils play an essential role in host defense against microbial pathogens and in the
inflammatory reaction. Upon activation, neutrophils produce superoxide anion ( $${\text{O}}_2 ^…

Potential role of the “NADPH oxidases”(NOX/DUOX) family in cystic fibrosis

…, MJ Foglietti, MA Gougerot-Pocidalo, M Bernard… - Annales de biologie …, 2008 - jle.com
La mucoviscidose est une maladie génétique létale très répandue dans les populations
caucasiennes; elle est due à une mutation sur un gène situé sur le chromosome 7, codant pour …

Killing of Aspergillus fumigatus by Alveolar Macrophages Is Mediated by Reactive Oxidant Intermediates

…, MA Gougerot-Pocidalo, M Sanchez Perez… - Infection and …, 2003 - Am Soc Microbiol
Phagocytosis and mechanisms of killing of Aspergillus fumigatus conidia by murine alveolar
macrophages (AM), which are the main phagocytic cells of the innate immunity of the lung, …

Pyogenic bacterial infections in humans with IRAK-4 deficiency

…, NK Day, RA Good, MA Gougerot-Pocidalo… - Science, 2003 - science.org
Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily share
an intracytoplasmic Toll–IL-1 receptor (TIR) domain, which mediates recruitment of the …

NAD (P) H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells

…, A Vandewalle, MA Gougerot-Pocidalo… - … and cellular biology, 2004 - Taylor & Francis
The mechanisms involved in the cytotoxic action of oxysterols in the pathogenesis of
atherosclerosis still remain poorly understood. Among the major oxysterols present in oxidized low-…

Physiologie des polynucléaires neutrophiles humains

…, J El Benna, MA Gougerot-Pocidalo - Revue francophone des …, 2014 - Elsevier
Les polynucléaires neutrophiles humains (PN) sont un des pivots de l’immunité innée et
constituent un puissant système de défense de l’homme contre les agents pathogènes …

Phosphorylation of p47phox Sites by PKC α, βΙΙ, δ, and ζ:  Effect on Binding to p22phox and on NADPH Oxidase Activation

A Fontayne, PMC Dang, MA Gougerot-Pocidalo… - Biochemistry, 2002 - ACS Publications
Production of superoxide anions by the multicomponent enzyme of human neutrophil NADPH
oxidase is accompanied by extensive phosphorylation of p47 phox , one of its cytosolic …

[HTML][HTML] A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

…, ON Jensen, MA Gougerot-Pocidalo… - The Journal of …, 2006 - Am Soc Clin Investig
Neutrophil NADPH oxidase plays a key role in host defense and in inflammation by releasing
large amounts of superoxide and other ROSs. Proinflammatory cytokines such as GM-CSF …