User profiles for M. Giembycz

Mark Giembycz

Professor of Pulmonary Pharmacology, University of Calgary
Verified email at ucalgary.ca
Cited by 14098

Pharmacology of the eosinophil

MA Giembycz, MA Lindsay - Pharmacological reviews, 1999 - ASPET
Using a compound microscope and the blood of several animals (including the elephant!),
the English anatomist, TW Jones, discovered, in 1846, that some white blood cells contained …

Prostanoid receptor antagonists: development strategies and therapeutic applications

RL Jones, MA Giembycz… - British journal of …, 2009 - Wiley Online Library
Identification of the primary products of cyclo‐oxygenase (COX)/prostaglandin synthase(s),
which occurred between 1958 and 1976, was followed by a classification system for …

[HTML][HTML] Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis

BLJ Webb, SJ Hirst, MA Giembycz - British journal of pharmacology, 2000 - ncbi.nlm.nih.gov
… Activation of Ras results in recruitment to the membrane of Raf-1 and phosphorylation
and activation of MEK-1 (MAP kinase/ERK-kinase activating kinase). MEK-1 directly …

Experimental design and analysis and their reporting II: Updated and simplified guidance for authors and peer reviewers

…, CH George, MA Giembycz… - British journal of …, 2018 - Wiley Online Library
This article updates the guidance published in 2015 for authors submitting papers to British
Journal of Pharmacology (Curtis et al., 2015) and is intended to provide the rubric for peer …

[HTML][HTML] Experimental design and analysis and their reporting: new guidance for publication in BJP

…, SPA Alexander, MA Giembycz… - British journal of …, 2015 - ncbi.nlm.nih.gov
This editorial is part of a series describing changes in the guidelines for authors making
submissions to the British Journal of Pharmacology (BJP)(McGrath and Curtis, 2015); McGrath …

[HTML][HTML] Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

…, G Cirino, JR Docherty, MA Giembycz… - British journal of …, 2018 - ncbi.nlm.nih.gov
Reproducibility is a current concern for everyone involved in the conduct and publication of
biomedical research. Recent attempts testing reproducibility, particularly the reproducibility …

Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4

…, O Kornmann, R Buhl, SV Culpitt, MA Giembycz… - Chest, 2003 - Elsevier
Study objectives: Neutrophilic inflammation is a major feature of COPD. Several factors in
bronchial secretions have been identified as chemoattractants for neutrophils. The present …

Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and …

AJ Thorley, PA Ford, MA Giembycz… - The journal of …, 2007 - journals.aai.org
Bacterial colonization is a secondary feature of many lung disorders associated with elevated
cytokine levels and increased leukocyte recruitment. We hypothesized that, alongside …

Delayed eosinophil apoptosis in asthma

H Kankaanranta, MA Lindsay, MA Giembycz… - Journal of Allergy and …, 2000 - Elsevier
Background: Eosinophilic inflammation of the airways is a key characteristic of asthma. A
defect in apoptosis might contribute to the chronic tissue eosinophilia associated with asthma. …

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T‐lymphocytes: role in regulating proliferation and the biosynthesis of …

MA Giembycz, CJ Corrigan, J Seybold… - British journal of …, 1996 - Wiley Online Library
… were terminated by the addition of 300,ul ice-cold trichloroacetic acid (TCA; 1 M), centrifuged
to precipitate particulate material and the supernatants neutralised. Aliquots (500 ,ul) of the …