User profiles for M. Colonna
Marco ColonnaWashington University St Louis Verified email at wustl.edu Cited by 110724 |
Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …
Innate lymphoid cells—a proposal for uniform nomenclature
Innate lymphoid cells (ILCs) are a family of developmentally related cells that are involved
in immunity and in tissue development and remodelling. Recent research has identified …
in immunity and in tissue development and remodelling. Recent research has identified …
[PDF][PDF] Innate lymphoid cells: 10 years on
Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen
receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and are …
receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and are …
[HTML][HTML] A unique microglia type associated with restricting development of Alzheimer's disease
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD onset …
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD onset …
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
…, H Nakajima, A Lanzavecchia, M Colonna - Nature medicine, 1999 - nature.com
We have identified two cell subsets in human blood based on the lack of lineage markers (lin–)
and the differential expression of immunoglobulin-like transcript receptor 1 (ILT1) and …
and the differential expression of immunoglobulin-like transcript receptor 1 (ILT1) and …
[HTML][HTML] TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor
that triggers intracellular protein tyrosine phosphorylation. Recent genome-wide association …
that triggers intracellular protein tyrosine phosphorylation. Recent genome-wide association …
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
…, JKM Lennerz, JM Doherty, JC Mills, M Colonna - Nature, 2009 - nature.com
Natural killer (NK) cells are classically viewed as lymphocytes that provide innate surveillance
against virally infected cells and tumour cells through the release of cytolytic mediators …
against virally infected cells and tumour cells through the release of cytolytic mediators …
Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus
The innate immune system recognizes viral dsRNA through two distinct pathways; the Toll-like
receptor 3 (TLR3) pathway detects dsRNA phagocytosed in endosomes; the helicases …
receptor 3 (TLR3) pathway detects dsRNA phagocytosed in endosomes; the helicases …
[HTML][HTML] Plasmacytoid dendritic cells in immunity
Human and mouse plasmacytoid dendritic cells have been shown to correspond to a specialized
cell population that produces large amounts of type I interferons in response to viruses, …
cell population that produces large amounts of type I interferons in response to viruses, …
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
A Bouchon, F Facchetti, MA Weigand, M Colonna - nature, 2001 - nature.com
Host innate responses to bacterial infections are primarily mediated by neutrophils and
monocytes/macrophages 1 , 2 . These cells express pattern recognition receptors (PRRs) that …
monocytes/macrophages 1 , 2 . These cells express pattern recognition receptors (PRRs) that …