Human breast cancer is usually caused by genetic alterations of somatic cells of the breast,
but occasionally, susceptibility to the disease is inherited. Mapping the genes responsible for …

Activating B-RAF(V600E) (also known as BRAF) kinase mutations occur in ∼7% of human
malignancies and ∼60% of melanomas 1 . Early clinical experience with a novel class I RAF-…

Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain
elusive. We hypothesize that individually rare structural variants contribute to the illness. …

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1–42…

High levels of familial Amyotrophic Lateral Sclerosis (ALS)-linked SOD1 mutants G93A and
G37R were previously shown to mediate disease in mice through an acquired toxic property. …

Mutations in Cu/Zn superoxide dismutase (SOD1) cause a subset of cases of familial
amyotrophic lateral sclerosis. Four lines of mice accumulating one of these mutant proteins (G37R) …

Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and γ-secretase
to release amyloid peptides (Aβ40 and 42) that aggregate to form senile plaques in the …

The majority of early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations
in two related genesPS1 and PS2, located on chromosome 14 and 1, respectively. Using …

… N-5 line, which expresses Hu PS1-A246E (Thinakaran et al., 1996; Lee et al., 1997). Thus,
even when … Increased coso and Lee Martin for critical review of neuropathological materi- …

Draft genome sequences have been determined for the soybean pathogen Phytophthora
sojae and the sudden oak death pathogen Phytophthora ramorum. Oömycetes such as these …