User profiles for M. G. Semple
 | Malcolm G SempleProfessor of Child Health and Outbreak Medicine, University of Liverpool Verified email at liverpool.ac.uk Cited by 35196 |
[HTML][HTML] A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a …
…, M Roderick, BR Scholefield, MG Semple… - The Lancet Child & …, 2021 - thelancet.com
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS)
is a novel condition that was first reported in April, 2020. We aimed to develop a national …
is a novel condition that was first reported in April, 2020. We aimed to develop a national …
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study
Objective To characterise the clinical features of patients admitted to hospital with coronavirus
disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave …
disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave …
[HTML][HTML] Clinical features and management of human monkeypox: a retrospective observational study in the UK
… brincidofovir (200 mg once a week orally), all of whom developed elevated liver enzymes
resulting in cessation of therapy. One patient was treated with tecovirimat (600 mg twice daily …
resulting in cessation of therapy. One patient was treated with tecovirimat (600 mg twice daily …
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C …
Objective To develop and validate a pragmatic risk score to predict mortality in patients admitted
to hospital with coronavirus disease 2019 (covid-19). Design Prospective observational …
to hospital with coronavirus disease 2019 (covid-19). Design Prospective observational …
[PDF][PDF] SARS-CoV-2 Omicron-B. 1.1. 529 leads to widespread escape from neutralizing antibody responses
…, T Malik, PJM Openshaw, JK Baillie, MG Semple… - Cell, 2022 - cell.com
On 24 th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529
was announced, containing far more mutations in Spike (S) than previously reported …
was announced, containing far more mutations in Spike (S) than previously reported …
[HTML][HTML] Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
…, BM Kessler, JW Fry, NF Schwabe, MG Semple… - Nature …, 2020 - nature.com
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines
and therapeutics will depend on understanding viral immunity. We studied T cell memory …
and therapeutics will depend on understanding viral immunity. We studied T cell memory …
[HTML][HTML] Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults
…, P Mande, JS Nguyen-Van-Tam, MG Semple… - Nature Medicine, 2022 - nature.com
… As per protocol, these first ten challenged participants were assigned to receive pre-emptive
remdesivir (100 mg intravenously for 5 days) once two consecutive 12-hourly nose or throat …
remdesivir (100 mg intravenously for 5 days) once two consecutive 12-hourly nose or throat …
[HTML][HTML] Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
…, M Richardson, M Rowland, MG Semple… - The Lancet …, 2021 - thelancet.com
Background The impact of COVID-19 on physical and mental health and employment after
hospitalisation with acute disease is not well understood. The aim of this study was to …
hospitalisation with acute disease is not well understood. The aim of this study was to …
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study
… Plus elevated markers of inflammation (C reactive protein ≥60 mg/L or ferritin ≥200 mg/L
at any point during admission; cut-offs chosen after expert discussion) 4. Plus no other …
at any point during admission; cut-offs chosen after expert discussion) 4. Plus no other …
Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study
Objective To derive and validate a risk prediction algorithm to estimate hospital admission
and mortality outcomes from coronavirus disease 2019 (covid-19) in adults. Design …
and mortality outcomes from coronavirus disease 2019 (covid-19) in adults. Design …