Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
…, R Siebert, PE Slagboom, P Soininen, L Stolk… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
…, M Marongiu, PF McArdle, AV Smith, L Stolk… - Nature …, 2010 - nature.com
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …
association studies in 87,802 women of European descent, with replication in up to 14,731 …
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
…, F Rivadeneira, J Van Rooij, L Stolk… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study
…, MC Castaņo-Betancourt, K Estrada, L Stolk… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE Individuals with type 2 diabetes have increased fracture risk despite higher
bone mineral density (BMD). Our aim was to examine the influence of glucose control on …
bone mineral density (BMD). Our aim was to examine the influence of glucose control on …
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
…, KL Lunetta, N Pervjakova, DI Chasman, L Stolk… - Nature …, 2015 - nature.com
Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …
genome-wide association studies (GWAS) in 38,968 women of European descent, with …
[HTML][HTML] Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
…, I Malkina, JB Richards, N Hammond, L Stolk… - PLoS …, 2009 - journals.plos.org
Recent genome-wide (GW) scans have identified several independent loci affecting human
stature, but their contribution through the different skeletal components of height is still poorly …
stature, but their contribution through the different skeletal components of height is still poorly …
[HTML][HTML] Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet
there is little consensus regarding its aetiology. Here we perform a genome-wide …
there is little consensus regarding its aetiology. Here we perform a genome-wide …