Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis
…, BR Jones, FB McMahon, LA Gleaves… - … of Physiology-Lung …, 2010 - journals.physiology.org
Single-dose intratracheal bleomycin has been instrumental for understanding fibrotic lung
remodeling, but fails to recapitulate several features of idiopathic pulmonary fibrosis (IPF). …
remodeling, but fails to recapitulate several features of idiopathic pulmonary fibrosis (IPF). …
Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
…, AH Hasty, KJ Carter, LA Gleaves… - Proceedings of the …, 1997 - National Acad Sciences
Macrophage-derived foam cells express apolipoprotein E (apoE) abundantly in atherosclerotic
lesions. To examine the physiologic role of apoE secretion by the macrophage in …
lesions. To examine the physiologic role of apoE secretion by the macrophage in …
[HTML][HTML] Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages
S Fazio, AS Major, LL Swift, LA Gleaves… - The Journal of …, 2001 - Am Soc Clin Investig
During atherogenesis, circulating macrophages migrate into the subendothelial space,
internalize cholesterol-rich lipoproteins, and become foam cells by progressively accumulating …
internalize cholesterol-rich lipoproteins, and become foam cells by progressively accumulating …
[HTML][HTML] Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo
VR Babaev, S Fazio, LA Gleaves… - The Journal of …, 1999 - Am Soc Clin Investig
Expression of lipoprotein lipase (LPL) by the macrophage has been proposed to promote
foam cell formation and atherosclerosis, primarily on the basis of in vitro studies. LPL-deficient …
foam cell formation and atherosclerosis, primarily on the basis of in vitro studies. LPL-deficient …
Macrophage TNF-α contributes to insulin resistance and hepatic steatosis in diet-induced obesity
…, OP McGuinness, L Gleaves… - American Journal …, 2007 - journals.physiology.org
Obesity is commonly associated with development of insulin resistance and systemic evidence
of inflammation. Macrophages contribute to inflammatory amplification in obesity and …
of inflammation. Macrophages contribute to inflammatory amplification in obesity and …
[HTML][HTML] Bronchoscopic cryobiopsy for the diagnosis of diffuse parenchymal lung disease
…, JM Pritchett, WR Mason, L Sivarajan, LA Gleaves… - PloS one, 2013 - journals.plos.org
Background Although in some cases clinical and radiographic features may be sufficient to
establish a diagnosis of diffuse parenchymal lung disease (DPLD), surgical lung biopsy is …
establish a diagnosis of diffuse parenchymal lung disease (DPLD), surgical lung biopsy is …
Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease
…, ME McConaha, BR Jones, LA Gleaves… - American journal of …, 2015 - atsjournals.org
Rationale: Asymptomatic relatives of patients with familial interstitial pneumonia (FIP), the
inherited form of idiopathic interstitial pneumonia, carry increased risk for developing interstitial …
inherited form of idiopathic interstitial pneumonia, carry increased risk for developing interstitial …
A critical role for macrophages in promotion of urethane-induced lung carcinogenesis
…, AG McLoed, FB McMahon, LA Gleaves… - The Journal of …, 2011 - journals.aai.org
Macrophages have established roles in tumor growth and metastasis, but information about
their role in lung tumor promotion is limited. To assess the role of macrophages in lung …
their role in lung tumor promotion is limited. To assess the role of macrophages in lung …
Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension
…, N Penner, KB Maynard, L Gleaves… - American journal of …, 2014 - atsjournals.org
Rationale: Shorter survival in heritable pulmonary arterial hypertension (HPAH), often due
to BMPR2 mutation, has been described in association with impaired right ventricle (RV) …
to BMPR2 mutation, has been described in association with impaired right ventricle (RV) …
Reduced atherosclerotic lesions in mice deficient for total or macrophage-specific expression of scavenger receptor-A
VR Babaev, LA Gleaves, KJ Carter… - … , and vascular biology, 2000 - Am Heart Assoc
The absence of the scavenger receptor A (SR-A)-I/II has produced variable effects on
atherosclerosis in different murine models. Therefore, we examined whether SR-AI/II deficiency …
atherosclerosis in different murine models. Therefore, we examined whether SR-AI/II deficiency …