User profiles for Lilit Nersisyan
Lilit NersisyanArmenian Bioinformatics Institute, Karolinska Institutet Verified email at abi.am Cited by 578 |
Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome
…, S Siebert, C Grimm, L Nersisyan… - The Journal of …, 2017 - Wiley Online Library
Colorectal cancer (CRC) arising in Lynch syndrome (LS) comprises tumours with constitutional
mutations in DNA mismatch repair genes. There is still a lack of whole‐genome and …
mutations in DNA mismatch repair genes. There is still a lack of whole‐genome and …
[HTML][HTML] Autoimmunity and autoinflammation: a systems view on signaling pathway dysregulation profiles
A Arakelyan, L Nersisyan, D Poghosyan… - PLoS …, 2017 - journals.plos.org
Introduction Autoinflammatory and autoimmune disorders are characterized by aberrant
changes in innate and adaptive immunity that may lead from an initial inflammatory state to an …
changes in innate and adaptive immunity that may lead from an initial inflammatory state to an …
[HTML][HTML] Telomere length maintenance and its transcriptional regulation in lynch syndrome and sporadic colorectal carcinoma
Background: Activation of telomere maintenance mechanisms (TMMs) is a hallmark of most
cancers, and is required to prevent genome instability and to establish cellular immortality …
cancers, and is required to prevent genome instability and to establish cellular immortality …
[PDF][PDF] Improved computational analysis of ribosome dynamics from 5′ P degradome data using fivepseq
L Nersisyan, M Ropat… - NAR Genomics and …, 2020 - academic.oup.com
In eukaryotes, 5′–3′ co-translation degradation machinery follows the last translating
ribosome providing an in vivo footprint of its position. Thus, 5′ monophosphorylated (5′P) …
ribosome providing an in vivo footprint of its position. Thus, 5′ monophosphorylated (5′P) …
[HTML][HTML] Computel: computation of mean telomere length from whole-genome next-generation sequencing data
L Nersisyan, A Arakelyan - PLoS one, 2015 - journals.plos.org
Telomeres are the ends of eukaryotic chromosomes, consisting of consecutive short repeats
that protect chromosome ends from degradation. Telomeres shorten with each cell division, …
that protect chromosome ends from degradation. Telomeres shorten with each cell division, …
[HTML][HTML] Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF). They
confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and …
confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and …
KEGGParser: parsing and editing KEGG pathway maps in Matlab
A Arakelyan, L Nersisyan - Bioinformatics, 2013 - academic.oup.com
KEGG pathway database is a collection of manually drawn pathway maps accompanied
with KGML format files intended for use in automatic analysis. KGML files, however, do not …
with KGML format files intended for use in automatic analysis. KGML files, however, do not …
Gene set-and pathway-centered knowledge discovery assigns transcriptional activation patterns in brain, blood, and colon cancer: a bioinformatics perspective
L Nersisyan, H Löffler-Wirth, A Arakelyan… - International Journal of …, 2014 - igi-global.com
Genome-wide ‘omics'-assays provide a comprehensive view on the molecular landscapes
of healthy and diseased cells. Bioinformatics traditionally pursues a ‘gene-centered'view by …
of healthy and diseased cells. Bioinformatics traditionally pursues a ‘gene-centered'view by …
[HTML][HTML] Footprints of sepsis framed within community acquired pneumonia in the blood transcriptome
L Hopp, H Loeffler-Wirth, L Nersisyan… - Frontiers in …, 2018 - frontiersin.org
We analyzed the blood transcriptome of sepsis framed within community-acquired pneumonia
(CAP) and characterized its molecular and cellular heterogeneity in terms of functional …
(CAP) and characterized its molecular and cellular heterogeneity in terms of functional …
[HTML][HTML] Transcriptomic maps of colorectal liver metastasis: machine learning of gene activation patterns and epigenetic trajectories in support of precision medicine
…, D Underwood, G Armen, A Arakelyan, L Nersisyan… - Cancers, 2023 - mdpi.com
Simple Summary Liver metastasis is a significant factor contributing to mortality associated
with colorectal cancer. Establishing the biological mechanisms of metastasis is crucial for …
with colorectal cancer. Establishing the biological mechanisms of metastasis is crucial for …