User profiles for Lilit Nersisyan

Lilit Nersisyan

Armenian Bioinformatics Institute, Karolinska Institutet
Verified email at abi.am
Cited by 578

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome

…, S Siebert, C Grimm, L Nersisyan… - The Journal of …, 2017 - Wiley Online Library
Colorectal cancer (CRC) arising in Lynch syndrome (LS) comprises tumours with constitutional
mutations in DNA mismatch repair genes. There is still a lack of whole‐genome and …

[HTML][HTML] Autoimmunity and autoinflammation: a systems view on signaling pathway dysregulation profiles

A Arakelyan, L Nersisyan, D Poghosyan… - PLoS …, 2017 - journals.plos.org
Introduction Autoinflammatory and autoimmune disorders are characterized by aberrant
changes in innate and adaptive immunity that may lead from an initial inflammatory state to an …

[HTML][HTML] Telomere length maintenance and its transcriptional regulation in lynch syndrome and sporadic colorectal carcinoma

L Nersisyan, L Hopp, H Loeffler-Wirth, J Galle… - Frontiers in …, 2019 - frontiersin.org
Background: Activation of telomere maintenance mechanisms (TMMs) is a hallmark of most
cancers, and is required to prevent genome instability and to establish cellular immortality …

[PDF][PDF] Improved computational analysis of ribosome dynamics from 5′ P degradome data using fivepseq

L Nersisyan, M Ropat… - NAR Genomics and …, 2020 - academic.oup.com
In eukaryotes, 5′–3′ co-translation degradation machinery follows the last translating
ribosome providing an in vivo footprint of its position. Thus, 5′ monophosphorylated (5′P) …

[HTML][HTML] Computel: computation of mean telomere length from whole-genome next-generation sequencing data

L Nersisyan, A Arakelyan - PLoS one, 2015 - journals.plos.org
Telomeres are the ends of eukaryotic chromosomes, consisting of consecutive short repeats
that protect chromosome ends from degradation. Telomeres shorten with each cell division, …

[HTML][HTML] Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics

…, S Huch, M Kasari, H Takada, L Nersisyan… - Nature …, 2022 - nature.com
PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF). They
confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and …

KEGGParser: parsing and editing KEGG pathway maps in Matlab

A Arakelyan, L Nersisyan - Bioinformatics, 2013 - academic.oup.com
KEGG pathway database is a collection of manually drawn pathway maps accompanied
with KGML format files intended for use in automatic analysis. KGML files, however, do not …

Gene set-and pathway-centered knowledge discovery assigns transcriptional activation patterns in brain, blood, and colon cancer: a bioinformatics perspective

L Nersisyan, H Löffler-Wirth, A Arakelyan… - International Journal of …, 2014 - igi-global.com
Genome-wide ‘omics'-assays provide a comprehensive view on the molecular landscapes
of healthy and diseased cells. Bioinformatics traditionally pursues a ‘gene-centered'view by …

[HTML][HTML] Footprints of sepsis framed within community acquired pneumonia in the blood transcriptome

L Hopp, H Loeffler-Wirth, L Nersisyan… - Frontiers in …, 2018 - frontiersin.org
We analyzed the blood transcriptome of sepsis framed within community-acquired pneumonia
(CAP) and characterized its molecular and cellular heterogeneity in terms of functional …

[HTML][HTML] Transcriptomic maps of colorectal liver metastasis: machine learning of gene activation patterns and epigenetic trajectories in support of precision medicine

…, D Underwood, G Armen, A Arakelyan, L Nersisyan… - Cancers, 2023 - mdpi.com
Simple Summary Liver metastasis is a significant factor contributing to mortality associated
with colorectal cancer. Establishing the biological mechanisms of metastasis is crucial for …