[HTML][HTML] Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis

A Edris, S De Feyter, T Maes, G Joos, L Lahousse - Respiratory research, 2019 - Springer
Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging,
we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce …

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

…, R Kumar, A Kumar, M Kuokkanen, L Lahousse… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

…, AA Litonjua, P Bakke, A Gulsvik, L Lahousse… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide 1 .
We performed a genetic association study in 15,256 cases and 47,936 controls, with …

Factors influencing SARS-CoV-2 RNA concentrations in wastewater up to the sampling stage: A systematic review

…, ALN van Nuijs, P Delputte, L Lahousse - Science of the Total …, 2022 - Elsevier
Wastewater-based surveillance (WBS) for SARS-CoV-2 RNA is a promising complementary
approach to monitor community viral circulation. A myriad of factors, however, can influence …

Sarcopenia in COPD: a systematic review and meta-analysis

E Benz, K Trajanoska, L Lahousse… - European respiratory …, 2019 - Eur Respiratory Soc
COPD is associated with a progressive loss of muscle mass and function. However, there is
an unmet need to define and standardise methods to estimate the prevalence of sarcopenia …

[HTML][HTML] Chronic obstructive pulmonary disease and cerebrovascular disease: a comprehensive review

L Lahousse, H Tiemeier, MA Ikram, GG Brusselle - Respiratory medicine, 2015 - Elsevier
Along with the aging population, the public health burden of cerebrovascular disease is
increasing. Cerebral small vessel disease and accumulation of brain pathology associate with …

[HTML][HTML] Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary …

…, SRA Wijnant, L Lahousse… - Nature …, 2023 - nature.com
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung …

[HTML][HTML] Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study

…, BH Stricker, GG Brusselle, L Lahousse - European journal of …, 2016 - Springer
COPD is the third leading cause of death in the world and its global burden is predicted to
increase further. Even though the prevalence of COPD is well studied, only few studies …

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

…, JJ Yim, X Zhou, Y Bossé, A Manichaikul, L Lahousse… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction

…, AL James, KT Khaw, L Lahousse… - American journal of …, 2012 - atsjournals.org
Rationale: Genome-wide association studies (GWAS) have identified loci influencing lung
function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are …