BACKGROUND: The pathology of pediatric severe therapy-resistant asthma (STRA) is little
understood. OBJECTIVES: We hypothesized that STRA in children is characterized by …

Background Two distinct, stable inflammatory phenotypes have been described in adults
with asthma: eosinophilic and non-eosinophilic. Treatment strategies based on these …

Background Parental smoking is known to worsen asthma symptoms in children and to make
them refractory to asthma treatment, but the molecular mechanism is unclear. Oxidative …

Background Studies in cystic fibrosis (CF) generally focus on inflammation present in the
airway lumen. Little is known about inflammation occurring in the airway wall, the site ultimately …

2. Toffoli S, Michiels C. Intermittent hypoxia is a key regulator of cancer cell and endothelial
cell interplay in tumours. FEBS J 2008; 275: 2991–3002. 3. Almendros I, Montserrat JM, …

Background Narrow band imaging (NBI) can accurately discriminate gastritis but premalignant
lesions (PMLs) are difficult to detect. Aims The purpose of this study was to compare white …

Background The bronchial epithelium and underlying reticular basement membrane (RBM)
have a close spatial and functional inter-relationship and are considered an epithelial–…

Objective: Long-term treatment of asthmatic children with low and moderate doses of inhaled
corticosteroids (ICS) may result in mild adrenal suppression. Various associations have …

Non alcoholic fatty liver disease (NAFLD) is a part of the metabolic syndrome which also
comprises obesity, dyslipidaemia, type 2 diabetes mellitus and hypertension. The importance of …

Crohn s disease is a well known inflammatory disease of unknown origin. It appears mostly
at young ages and the need for a long lasting therapy with immunosuppressing drugs makes …