Prematurely born infants who require oxygen therapy often develop bronchopulmonary
dysplasia (BPD), a debilitating disorder characterized by pronounced alveolar hypoplasia. …

Cell surface–associated proteolysis plays a crucial role in the migration of mononuclear
phagocytes to sites of inflammation. The glycolytic enzyme enolase-1 (ENO-1) binds …

Background Lung eosinophilia is a hallmark of asthma, and eosinophils are believed to play
a crucial role in the pathogenesis of allergic inflammatory diseases. Short-chain fatty acids (…

Rationale: Resident alveolar macrophages have been attributed a crucial role in host
defense toward pulmonary infection. Their contribution to alveolar repair processes, however, …

The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …

Rationale: The development of pulmonary hypertension (PH) in patients with idiopathic
pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) is associated with …

Increasing evidence points towards an inflammatory component underlying pulmonary
hypertension. However, the conclusive characterisation of multiple inflammatory cell populations …

Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine involved
in acute lung injury and other processes such as wound repair and tumor growth. MIF …

Particulates from air pollution are implicated in causing or exacerbating respiratory and
systemic cardiovascular diseases and are thought to be among the leading causes of morbidity …

Our systematic analysis of anion channels and transporters in idiopathic pulmonary arterial
hypertension (IPAH) showed marked upregulation of the Cl − channel TMEM16A gene. We …