Asthma: Mechanisms of Disease Persistence and Progression

L Cohn, JA Elias, GL Chupp - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract When asthma is diagnosed, eosinophilic inflammation and airway remodeling are
established in the bronchial airways and can no longer be separated as cause and effect …

[HTML][HTML] Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

DH Zhang, L Cohn, P Ray, K Bottomly, A Ray - Journal of Biological …, 1997 - ASBMB
Interleukin-5 (IL-5), which is produced by CD4 + T helper 2 (Th2) cells, but not by Th1 cells,
plays a key role in the development of eosinophilia in asthma. Despite increasing evidence …

Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation

Z Zhu, T Zheng, RJ Homer, YK Kim, NY Chen, L Cohn… - Science, 2004 - science.org
Chitin is a surface component of parasites and insects, and chitinases are induced in lower
life forms during infections with these agents. Although chitin itself does not exist in humans, …

Resolution of lung inflammation by CD44

P Teder, RW Vandivier, D Jiang, J Liang, L Cohn… - Science, 2002 - science.org
Successful repair after tissue injury and inflammation requires resolution of the inflammatory
response and removal of extracellular matrix breakdown products. We have examined …

Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung

…, S Chapoval, V Bhandari, MJ Kang, L Cohn… - Nature medicine, 2004 - nature.com
Exaggerated levels of VEGF (vascular endothelial growth factor) are present in persons with
asthma, but the role(s) of VEGF in normal and asthmatic lungs has not been defined. We …

A critical role for NF-κB in GATA3 expression and TH2 differentiation in allergic airway inflammation

J Das, CH Chen, L Yang, L Cohn, P Ray, A Ray - Nature immunology, 2001 - nature.com
The transcription factor GATA-3 is expressed in T helper 2 (TH 2) but not TH 1 cells and plays
a critical role in TH 2 differentiation and allergic airway inflammation in vivo. Mice that lack …

Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production

L Cohn, RJ Homer, A Marinov, J Rankin… - The Journal of …, 1997 - rupress.org
Airway inflammation is believed to stimulate mucus production in asthmatic patients. Increased
mucus secretion is an important clinical symptom and contributes to airway obstruction in …

[HTML][HTML] TRPA1 is a major oxidant sensor in murine airway sensory neurons

…, CA Von Hehn, J Escalera, L Cohn… - The Journal of …, 2008 - Am Soc Clin Investig
Sensory neurons in the airways are finely tuned to respond to reactive chemicals threatening
airway function and integrity. Nasal trigeminal nerve endings are particularly sensitive to …

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

…, H Matsuura, CA Da Silva, MH Sohn, L Cohn… - Journal of Experimental …, 2009 - rupress.org
Mouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40
are chitinase-like proteins that lack chitinase activity. Although YKL-40 is expressed in …

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

…, NJ Hayward, RJ Homer, L Cohn… - Proceedings of the …, 2009 - National Acad Sciences
Asthma is an inflammatory disorder caused by airway exposures to allergens and chemical
irritants. Studies focusing on immune, smooth muscle, and airway epithelial function …