The acute respiratory distress syndrome

LB Ware, MA Matthay - New England Journal of Medicine, 2000 - Mass Medical Soc
The acute respiratory distress syndrome is a common, devastating clinical syndrome of
acute lung injury that affects both medical and surgical patients. Since the last review of this …

[HTML][HTML] The acute respiratory distress syndrome

MA Matthay, LB Ware… - The Journal of clinical …, 2012 - Am Soc Clin Investig
… , R37HL51856, U01HL10871301, and R01HL101779 from the NHLBI; R01A1087674
and P01A1053194 from the National Institute of Allergy and Infectious Diseases), LB Ware (…

Acute pulmonary edema

LB Ware, MA Matthay - New England Journal of Medicine, 2005 - Mass Medical Soc
A 62-year-old man presents with a three-day history of progressive dyspnea, nonproductive
cough, and low-grade fever. His blood pressure is 100/60 mm Hg, his heart rate 110 beats …

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials

…, PE Parsons, BT Thompson, LB Ware… - The Lancet …, 2014 - thelancet.com
Background Subphenotypes have been identified within heterogeneous diseases such as
asthma and breast cancer, with important therapeutic implications. We assessed whether …

Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome

LB Ware, MA Matthay - American journal of respiratory and critical …, 2001 - atsjournals.org
Because experimental studies have shown that intact alveolar epithelial fluid transport
function is critical for resolution of pulmonary edema and acute lung injury, we measured net …

The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies

…, CR Martling, P Venge, E Siew, LB Ware… - Journal of the American …, 2011 - jacc.org
Objectives : The aim of this study was to test the hypothesis that, without diagnostic changes
in serum creatinine, increased neutrophil gelatinase-associated lipocalin (NGAL) levels …

Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS

…, GR Bernard, DL Hayden, DA Schoenfeld, LB Ware… - Chest, 2007 - Elsevier
Background The diagnostic criteria for acute lung injury (ALI) and ARDS utilize the Pao 2 /fraction
of inspired oxygen (Fio 2 ) [P/F] ratio measured by arterial blood gas analysis to assess …

Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy

KR Famous, K Delucchi, LB Ware… - American journal of …, 2017 - atsjournals.org
Rationale: We previously identified two acute respiratory distress syndrome (ARDS) subphenotypes
in two separate randomized controlled trials with differential response to positive end…

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

…, MJ Bacchetta, JE Loyd, CM Shaver, LB Ware… - Science …, 2020 - science.org
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic epithelial
remodeling and accumulation of extracellular matrix (ECM). To comprehensively define …

Pathophysiology of acute lung injury and the acute respiratory distress syndrome

LB Ware - Seminars in respiratory and critical care medicine, 2006 - thieme-connect.com
Since the adult respiratory distress syndrome was first described substantial progress has
been made in understanding the pathogenesis of this complex syndrome. This review …