The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

… Data are from Teppema and colleagues.14 … Data are from Teppema and colleagues. …
Dahan A, Teppema L. Influence of low‐dose anaesthetic agents on ventilatory control: where do we …

Background. We measured the effect of two weight adjusted iv doses (0.2 mg per 70 kg and
0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory …

Background. There is evidence from animal studies suggesting the existence of a ceiling effect
for buprenorphine-induced respiratory depression. To study whether an apparent ceiling …

Background Animal and human studies indicate the existence of important sex-related
differences in opioid-mediated behavior. In this study the authors examined the influence of …

In this study, Fos immunohistochemistry was used to map brainstem neuronal pathways
activated during hypercapnia and hypoxia. Conscious rats were exposed to six different gas …

A debate has raged since the discovery of central and peripheral respiratory chemoreceptors
as to whether the reflexes they mediate combine in an additive (ie, no interaction), …

Background Since propofol and remifentanil are frequently combined for monitored anesthesia
care, we examined the influence of the separate and combined administration of these …

N-methyl-d-aspartate receptor antagonism probably accounts for most of ketamine’s anesthetic
effects; its analgesic properties are mediated partly via N-methyl-d-aspartate and partly …

Background The involvement of the mu-opioid receptor (muOR) system in the control of
breathing, anesthetic potency, and morphine- and anesthesia-induced respiratory depression …