Common respiratory conditions of the newborn

DJ Gallacher, K Hart, S Kotecha - Breathe, 2016 - Eur Respiratory Soc
Key points Respiratory distress is a common presenting feature among newborn infants.
Prompt investigation to ascertain the underlying diagnosis and appropriate subsequent …

Inhaled corticosteroids alone and in combination with long-acting β2 receptor agonists to treat reduced lung function in preterm-born children: a randomized clinical …

N Goulden, M Cousins, K Hart, A Jenkins… - JAMA …, 2022 - jamanetwork.com
Importance Decreases in future lung function are a hallmark of preterm birth, but studies for
management of decreased lung function are limited. Objective To determine whether 12 …

[HTML][HTML] Association of early-life factors with prematurity-associated lung disease: prospective cohort study

K Hart, M Cousins, WJ Watkins… - European …, 2022 - Eur Respiratory Soc
Background Although bronchopulmonary dysplasia (BPD) is associated with lung function
deficits in childhood, many who develop BPD have normal lung function in childhood and …

[HTML][HTML] Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children

…, PA Lewis, SJ Kotecha, M Cousins, K Hart… - Respiratory …, 2023 - Springer
Introduction Although different phenotypes of lung disease after preterm birth have recently
been described, the underlying mechanisms associated with each phenotype are poorly …

[HTML][HTML] Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia

…, PA Lewis, SJ Kotecha, M Cousins, K Hart… - Scientific Reports, 2023 - nature.com
Despite evidence demonstrating persistent lung function deficits in preterm-born children,
especially in those who had bronchopulmonary dysplasia (BPD) in infancy, the underlying …

[HTML][HTML] Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia

…, PA Lewis, SJ Kotecha, M Cousins, K Hart… - Scientific Reports, 2023 - nature.com
Preterm-born children are at risk of long-term pulmonary deficits, including those who
developed bronchopulmonary dysplasia (BPD) in infancy, however the underlying mechanisms …

Image Phenotyping of Preterm-Born Children Using Hyperpolarized 129Xe Lung Magnetic Resonance Imaging and Multiple-Breath Washout

…, M Rao, G Norquay, AJ Swift, K Hart… - American Journal of …, 2023 - atsjournals.org
Rationale: Preterm birth is associated with low lung function in childhood, but little is known
about the lung microstructure in childhood. Objectives: We assessed the differential …

Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease

M Cousins, K Hart, SJ Kotecha, AJ Henderson… - Thorax, 2023 - thorax.bmj.com
Introduction Although obstructive airway disease has been shown to be associated with
prematurity, other spirometry phenotypes are less well described. Objectives We characterised …

Impaired exercise outcomes with significant bronchodilator responsiveness in children with prematurity‐associated obstructive lung disease

M Cousins, K Hart, EM Williams… - Pediatric …, 2022 - Wiley Online Library
Introduction Preterm‐born children have their normal in‐utero lung development interrupted,
thus are at risk of short‐ and long‐term lung disease. Spirometry and exercise capacity …

[HTML][HTML] Association of early and current life factors with telomere length in preterm-born children

EA Kotecha, L Zhang, A Aboklaish, M Cousins, K Hart… - Plos one, 2023 - journals.plos.org
Background Telomeres shorten after each cell division. Since preterm-born babies are
delivered early and often suffer from inflammatory conditions such as bronchopulmonary …