Background Recent studies suggest that lung microbiome dysbiosis, the disease associated
disruption of the lung microbial community, might play a key role in chronic obstructive …

Increased reactive oxygen species (ROS) have been implicated in the pathophysiology of
chronic obstructive pulmonary disease (COPD). This study examined the effect of exogenous …

In the healthy lung, macrophages maintain homeostasis by clearing inhaled particles,
bacteria, and removing apoptotic cells from the local pulmonary environment. However, in …

Chronic obstructive pulmonary disease (COPD) patients exhibit chronic inflammation, both in
the lung parenchyma and the airways, which is characterised by an increased infiltration of …

Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic
obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both …

Rationale: Human rhinovirus (HRV) is a common cause of chronic obstructive pulmonary
disease (COPD) exacerbations. Secondary bacterial infection is associated with more severe …

Rationale: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts.
Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics or single …

Chronic pulmonary conditions now account for 1 in 15 deaths in the US and mortality is
increasing. Chronic obstructive pulmonary disease (COPD) is due to become the 3rd largest …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) experience excess
cardiovascular morbidity and mortality, and exacerbations further increase the risk of such …

Alpha-1 antitrypsin deficiency (AATD) is a genetic condition characterised by low circulating
levels of alpha-1 antitrypsin (AAT), a serine proteinase inhibitor. The most common …