Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor
receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these …

Aberrant methylation of CpG islands acquired in tumor cells in promoter regions is one method
for loss of gene function. We determined the frequency of aberrant promoter methylation (…

Mutations in the epidermal growth factor receptor gene (EGFR) in lung cancers predict for
sensitivity to EGFR kinase inhibitors. HER2 (also known as NEU, EGFR2, or ERBB2) is a …

Background The role of inhaled corticosteroids (ICS) in chronic obstructive pulmonary
disease (COPD) has been the subject of much controversy. Major international guidelines …

Background: Most lung cancers are attributed to smoking. These cancers have been associated
with multiple genetic alterations and with the presence of preneoplastic bronchial lesions…

We investigated the frequency and function of mutations and increased copy number of the
PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes …

Particulate matter (PM) emissions involve a complex mixture of solid and liquid particles
suspended in a gas, where it is noted that PM emissions from diesel engines are a major …

Low-income and middle-income countries (LMICs) bear a disproportionately high burden of
the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including …

We review the molecular pathogenesis of lung cancer including alterations in dominant
oncogenes, recessive oncogenes/tumor suppressor genes, alterations in growth regulatory …

Lung cancer results from multiple changes in the genome of susceptible pulmonary cells
caused by exposure to carcinogens found in tobacco smoke, the environment, or the workplace…