Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death
worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease …

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality.
Cigarette smoke (CS) drives disease development and progression. The epithelial barrier is …

Epithelial cells line the lung mucosal surface and are the first line of defense against toxic
exposures to environmental insults, and their integrity is critical to lung health. An early finding …

Background Taking into consideration a recent surge of a lung injury condition associated
with electronic cigarette use, we devised an in vitro model of sub-chronic exposure of human …

The airway epithelium is subjected to insults such as cigarette smoke (CS), a primary cause
of chronic obstructive pulmonary disease (COPD) and serves as an excellent model to study …

Air-liquid interface (ALI) cultures are ex vivo models that are used extensively to study the
epithelium of patients with chronic respiratory diseases. However, the in vitro conditions …

Abstract Treatment options for high grade urothelial cancers are limited and have remained
largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule …

Measuring the time evolution of response of Normal Human Bronchial Epithelial (NHBE) cells
to aerosols is essential for understanding the pathogenesis of airway disease. This study …

Prostate cancer (PCa) is characterized by a unique dependence on optimal androgen
receptor (AR) activity where physiological androgen concentrations induce proliferation but …

Bladder cancer (BlCa) exhibits a gender disparity where men are three times more likely to
develop the malignancy than women suggesting a role for the androgen receptor (AR). Here …