[HTML][HTML] Understanding cellular redox homeostasis: A challenge for precision medicine
…, B Hochreiter, ML Zach, K Krenn, KU Klein - International journal of …, 2021 - mdpi.com
Living organisms use a large repertoire of anabolic and catabolic reactions to maintain their
physiological body functions, many of which include oxidation and reduction of substrates. …
physiological body functions, many of which include oxidation and reduction of substrates. …
[HTML][HTML] Impaired cerebrovascular autoregulation in patients with severe sepsis and sepsis-associated delirium
P Schramm, KU Klein, L Falkenberg, M Berres… - Critical care, 2012 - Springer
Introduction Sepsis-associated delirium (SAD) increases morbidity in septic patients and,
therefore, factors contributing to SAD should be further characterized. One possible …
therefore, factors contributing to SAD should be further characterized. One possible …
[HTML][HTML] Recent advances in understanding acute respiratory distress syndrome
…, V Tretter, R Ullrich, K Markstaller, KU Klein - …, 2018 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse lung injury,
which results in increased pulmonary vascular permeability and loss of aerated lung tissue. …
which results in increased pulmonary vascular permeability and loss of aerated lung tissue. …
Intermittent hypoxia causes inflammation and injury to human adult cardiac myocytes
…, VE Tretter, K Markstaller, KU Klein - Anesthesia & …, 2016 - journals.lww.com
BACKGROUND: Intermittent hypoxia may occur in a number of clinical scenarios, including
interruption of myocardial blood flow or breathing disorders such as obstructive sleep apnea. …
interruption of myocardial blood flow or breathing disorders such as obstructive sleep apnea. …
[HTML][HTML] Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized …
K Krenn, R Lucas, A Croizé, S Boehme, KU Klein… - Critical Care, 2017 - Springer
Background High-permeability pulmonary edema is a hallmark of acute respiratory distress
syndrome (ARDS) and is frequently accompanied by impaired alveolar fluid clearance (AFC)…
syndrome (ARDS) and is frequently accompanied by impaired alveolar fluid clearance (AFC)…
[HTML][HTML] Investigating disturbances of oxygen homeostasis: from cellular mechanisms to the clinical practice
…, S Böhme, R Ullrich, K Markstaller, KU Klein - Frontiers in …, 2020 - frontiersin.org
Soon after its discovery in the 18th century, oxygen was applied as a therapeutic agent to
treat severely ill patients. Lack of oxygen, commonly termed as hypoxia, is frequently …
treat severely ill patients. Lack of oxygen, commonly termed as hypoxia, is frequently …
Maternal serum mitochondrial DNA (mtDNA) levels are elevated in preeclampsia–a matched case-control study
…, P Wohlrab, J Ott, J Wojta, W Speidl, KU Klein… - Pregnancy …, 2018 - Elsevier
Objective Oxidative stress and mitochondrial dysfunction may play a crucial role in preeclampsia
(PE). The aim of this study was to investigate differences in maternal levels of serum-…
(PE). The aim of this study was to investigate differences in maternal levels of serum-…
Hyperoxia induces inflammation and cytotoxicity in human adult cardiac myocytes
…, J Wojta, R Ullrich, EV Tretter, K Markstaller, KU Klein - Shock, 2017 - journals.lww.com
Supplemental oxygen (O 2) is used as adjunct therapy in anesthesia, emergency, and intensive
care medicine. We hypothesized that excessive O 2 levels (hyperoxia) can directly injure …
care medicine. We hypothesized that excessive O 2 levels (hyperoxia) can directly injure …
Human cerebral microcirculation and oxygen saturation during propofol-induced reduction of bispectral index
KU Klein, K Fukui, P Schramm, A Stadie… - British journal of …, 2011 - academic.oup.com
Background Propofol reduces cerebral blood flow (CBF) secondary to cerebral metabolic
depression. However, in vitro and in vivo studies demonstrate that propofol directly dilates the …
depression. However, in vitro and in vivo studies demonstrate that propofol directly dilates the …
Laparoscopic inguinal hernia repair does not impair testicular perfusion
F Schier, S Turial, T Hückstädt, KU Klein… - Journal of pediatric …, 2008 - Elsevier
BACKGROUND: Laparoscopic inguinal hernia repair techniques close the internal ring with
a suture. Concern has been raised whether or not the testicular vessels are compromised …
a suture. Concern has been raised whether or not the testicular vessels are compromised …